Chlorine in PDB 2hkj: Topoisomerase VI-B Bound to Radicicol

All present enzymatic activity of Topoisomerase VI-B Bound to Radicicol:
5.99.1.3;

The structure of Topoisomerase VI-B Bound to Radicicol, PDB code: 2hkj was solved by K.D.Corbett, J.M.Berger, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 2.00
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	93.879, 111.398, 54.888, 90.00, 90.00, 90.00
R / Rfree (%)	16.7 / 20.9

The structure of Topoisomerase VI-B Bound to Radicicol also contains other interesting chemical elements:

Magnesium

(Mg)

1 atom

The binding sites of Chlorine atom in the Topoisomerase VI-B Bound to Radicicol (pdb code 2hkj). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Topoisomerase VI-B Bound to Radicicol, PDB code: 2hkj:

Chlorine binding site 1 out of 1 in the Topoisomerase VI-B Bound to Radicicol


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Topoisomerase VI-B Bound to Radicicol within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl501 b:18.5 occ:1.00 CL1 A:RDC501 0.0 18.5 1.0 C6 A:RDC501 1.8 18.1 1.0 C7 A:RDC501 2.8 18.7 1.0 C5 A:RDC501 2.8 18.2 1.0 O4 A:RDC501 2.9 17.2 1.0 C9 A:RDC501 3.0 21.6 1.0 C8 A:RDC501 3.0 19.1 1.0 O5 A:RDC501 3.1 23.9 1.0 ND2 A:ASN42 3.2 17.1 1.0 CE1 A:PHE90 3.3 14.1 1.0 CZ A:PHE90 3.4 18.7 1.0 CG1 A:VAL112 3.7 18.2 1.0 C10 A:RDC501 3.7 21.8 1.0 CB A:VAL112 4.1 19.9 1.0 C2 A:RDC501 4.1 18.1 1.0 C4 A:RDC501 4.1 19.0 1.0 CG2 A:VAL112 4.1 20.7 1.0 CG A:ASN42 4.2 19.1 1.0 CD1 A:PHE90 4.3 20.9 1.0 C11 A:RDC501 4.3 18.2 1.0 CE2 A:PHE90 4.4 19.4 1.0 CG2 A:VAL172 4.4 15.2 1.0 CB A:ASN42 4.5 17.9 1.0 C3 A:RDC501 4.6 18.7 1.0 O A:HOH549 4.8 21.3 1.0 O A:HOH578 4.9 24.2 1.0

K.D.Corbett, J.M.Berger. Structural Basis For Topoisomerase VI Inhibition By the Anti-HSP90 Drug Radicicol Nucleic Acids Res. V. 34 4269 2006.
ISSN: ISSN 0305-1048
PubMed: 16920739
DOI: 10.1093/NAR/GKL567