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Chlorine in PDB 2hvx: Discovery of Potent, Orally Active, Nonpeptide Inhibitors of Human Mast Cell Chymase By Using Structure-Based Drug Design
Enzymatic activity of Discovery of Potent, Orally Active, Nonpeptide Inhibitors of Human Mast Cell Chymase By Using Structure-Based Drug Design
All present enzymatic activity of Discovery of Potent, Orally Active, Nonpeptide Inhibitors of Human Mast Cell Chymase By Using Structure-Based Drug Design:
3.4.21.39;
3.4.21.39;
Protein crystallography data
The structure of Discovery of Potent, Orally Active, Nonpeptide Inhibitors of Human Mast Cell Chymase By Using Structure-Based Drug Design, PDB code: 2hvx
was solved by
M.N.Greco,
M.J.Hawkins,
E.T.Powell,
H.R.Almond,
L.De Garavilla,
Y.Wang,
L.A.Minor,
G.I.Wells,
E.Di Cera,
A.M.Cantwell,
S.N.Savvides,
B.P.Damiano,
B.E.Maryanoff,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 30.00 / 2.60 |
| Space group | P 43 |
| Cell size a, b, c (Å), α, β, γ (°) | 73.940, 73.940, 49.450, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 22.9 / 27.4 |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Discovery of Potent, Orally Active, Nonpeptide Inhibitors of Human Mast Cell Chymase By Using Structure-Based Drug Design
(pdb code 2hvx). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Discovery of Potent, Orally Active, Nonpeptide Inhibitors of Human Mast Cell Chymase By Using Structure-Based Drug Design, PDB code: 2hvx:
In total only one binding site of Chlorine was determined in the Discovery of Potent, Orally Active, Nonpeptide Inhibitors of Human Mast Cell Chymase By Using Structure-Based Drug Design, PDB code: 2hvx:
Chlorine binding site 1 out of 1 in 2hvx
Go back to
Chlorine Binding Sites List in 2hvx
Chlorine binding site 1 out
of 1 in the Discovery of Potent, Orally Active, Nonpeptide Inhibitors of Human Mast Cell Chymase By Using Structure-Based Drug Design
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Discovery of Potent, Orally Active, Nonpeptide Inhibitors of Human Mast Cell Chymase By Using Structure-Based Drug Design within 5.0Å range:
|
Reference:
M.N.Greco,
M.J.Hawkins,
E.T.Powell,
H.R.Almond,
L.De Garavilla,
J.Hall,
L.K.Minor,
Y.Wang,
T.W.Corcoran,
E.Di Cera,
A.M.Cantwell,
S.N.Savvides,
B.P.Damiano,
B.E.Maryanoff.
Discovery of Potent, Selective, Orally Active, Nonpeptide Inhibitors of Human Mast Cell Chymase. J.Med.Chem. V. 50 1727 2007.
ISSN: ISSN 0022-2623
PubMed: 17361995
DOI: 10.1021/JM0700619
Page generated: Sat Jul 20 07:57:16 2024
ISSN: ISSN 0022-2623
PubMed: 17361995
DOI: 10.1021/JM0700619
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