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Chlorine in PDB 2i0v: C-Fms Tyrosine Kinase in Complex with A Quinolone Inhibitor

Enzymatic activity of C-Fms Tyrosine Kinase in Complex with A Quinolone Inhibitor

All present enzymatic activity of C-Fms Tyrosine Kinase in Complex with A Quinolone Inhibitor:
2.7.10.1;

Protein crystallography data

The structure of C-Fms Tyrosine Kinase in Complex with A Quinolone Inhibitor, PDB code: 2i0v was solved by C.Schubert, C.Schalk-Hihi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 26.59 / 2.80
Space group H 3
Cell size a, b, c (Å), α, β, γ (°) 82.199, 82.199, 143.300, 90.00, 90.00, 120.00
R / Rfree (%) n/a / n/a

Chlorine Binding Sites:

The binding sites of Chlorine atom in the C-Fms Tyrosine Kinase in Complex with A Quinolone Inhibitor (pdb code 2i0v). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the C-Fms Tyrosine Kinase in Complex with A Quinolone Inhibitor, PDB code: 2i0v:

Chlorine binding site 1 out of 1 in 2i0v

Go back to Chlorine Binding Sites List in 2i0v
Chlorine binding site 1 out of 1 in the C-Fms Tyrosine Kinase in Complex with A Quinolone Inhibitor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of C-Fms Tyrosine Kinase in Complex with A Quinolone Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1000

b:29.5
occ:1.00
CL1 A:6C31000 0.0 29.5 1.0
C4 A:6C31000 1.7 25.1 1.0
C3 A:6C31000 2.7 26.8 1.0
C5 A:6C31000 2.7 23.5 1.0
CE A:LYS616 3.2 40.2 1.0
O A:ASP796 3.6 22.3 1.0
CG A:LYS616 3.8 35.4 1.0
CD2 A:PHE797 3.9 21.9 1.0
CA A:PHE797 4.0 24.5 1.0
C6 A:6C31000 4.0 25.6 1.0
C2 A:6C31000 4.0 28.3 1.0
CD A:LYS616 4.1 37.7 1.0
NZ A:LYS616 4.2 42.0 1.0
CG1 A:VAL596 4.3 24.2 1.0
C1 A:6C31000 4.5 27.8 1.0
CB A:PHE797 4.5 25.1 1.0
C A:ASP796 4.6 23.1 1.0
CB A:VAL596 4.6 26.9 1.0
CG2 A:VAL596 4.6 23.6 1.0
CG A:PHE797 4.7 22.9 1.0
C A:PHE797 4.7 25.4 1.0
CE2 A:PHE797 4.7 23.4 1.0
N A:PHE797 4.8 23.8 1.0
CB A:ALA800 4.8 23.9 1.0
N A:ALA800 4.9 26.4 1.0

Reference:

C.Schubert, C.Schalk-Hihi, G.T.Struble, H.C.Ma, I.P.Petrounia, B.Brandt, I.C.Deckman, R.J.Patch, M.R.Player, J.C.Spurlino, B.A.Springer. Crystal Structure of the Tyrosine Kinase Domain of Colony-Stimulating Factor-1 Receptor (Cfms) in Complex with Two Inhibitors. J.Biol.Chem. V. 282 4094 2007.
ISSN: ISSN 0021-9258
PubMed: 17132624
DOI: 10.1074/JBC.M608183200
Page generated: Thu Jul 10 22:39:13 2025

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