Chlorine in PDB 2ieh: Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer

Enzymatic activity of Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer

All present enzymatic activity of Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer:
3.6.4.4;

Protein crystallography data

The structure of Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer, PDB code: 2ieh was solved by I.Garcia-Saez, F.Kozielski, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	25.00 / 2.70
*Space group*	P 2₁ 2₁ 2₁
*Cell size a, b, c (Å), α, β, γ (°)*	69.370, 79.900, 159.860, 90.00, 90.00, 90.00
*R / R_free (%)*	23.4 / 28.1

Other elements in 2ieh:

The structure of Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer also contains other interesting chemical elements:

Magnesium	(Mg)	2 atoms
Potassium	(K)	1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer (pdb code 2ieh). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer, PDB code: 2ieh:

Chlorine binding site 1 out of 1 in 2ieh

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Chlorine Binding Sites List in 2ieh

Chlorine binding site 1 out of 1 in the Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl608 b:33.1 occ:1.00	NH1	A:ARG138	3.4	20.3	1.0
	NH2	A:ARG138	3.4	5.8	1.0
	O5	A:PG4606	3.6	54.4	1.0
	CZ	A:ARG138	3.9	16.9	1.0
	CA	A:PRO131	3.9	17.7	1.0
	CD1	A:ILE79	4.3	26.8	1.0
	CB	A:ILE79	4.4	5.6	1.0
	O	A:ASP130	4.4	19.7	1.0
	CB	A:PRO131	4.4	7.6	1.0
	O	A:GLU129	4.4	34.1	1.0
	C8	A:PG4606	4.5	54.3	1.0
	N	A:PRO131	4.5	14.3	1.0
	CG1	A:ILE79	4.6	2.9	1.0
	C	A:ASP130	4.7	18.4	1.0
	O	A:PRO131	4.8	26.0	1.0
	C	A:PRO131	4.8	20.9	1.0

Reference:

I.Garcia-Saez, S.Debonis, R.Lopez, F.Trucco, B.Rousseau, P.Thuery, F.Kozielski. Structure of Human EG5 in Complex with A New Monastrol-Based Inhibitor Bound in the R Configuration. J.Biol.Chem. V. 282 9740 2007.
ISSN: ISSN 0021-9258
PubMed: 17251189
DOI: 10.1074/JBC.M608883200

Page generated: Thu Jul 10 22:45:04 2025

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