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Chlorine in PDB 2jbk: Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Quisqualic Acid (Quisqualate, Alpha-Amino-3,5-Dioxo-1,2,4- Oxadiazolidine-2-Propanoic Acid)

Enzymatic activity of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Quisqualic Acid (Quisqualate, Alpha-Amino-3,5-Dioxo-1,2,4- Oxadiazolidine-2-Propanoic Acid)

All present enzymatic activity of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Quisqualic Acid (Quisqualate, Alpha-Amino-3,5-Dioxo-1,2,4- Oxadiazolidine-2-Propanoic Acid):
3.4.17.21;

Protein crystallography data

The structure of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Quisqualic Acid (Quisqualate, Alpha-Amino-3,5-Dioxo-1,2,4- Oxadiazolidine-2-Propanoic Acid), PDB code: 2jbk was solved by J.R.Mesters, K.Henning, R.Hilgenfeld, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 100.00 / 2.99
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 103.144, 130.758, 159.992, 90.00, 90.00, 90.00
R / Rfree (%) 21 / n/a

Other elements in 2jbk:

The structure of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Quisqualic Acid (Quisqualate, Alpha-Amino-3,5-Dioxo-1,2,4- Oxadiazolidine-2-Propanoic Acid) also contains other interesting chemical elements:

Calcium (Ca) 1 atom
Zinc (Zn) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Quisqualic Acid (Quisqualate, Alpha-Amino-3,5-Dioxo-1,2,4- Oxadiazolidine-2-Propanoic Acid) (pdb code 2jbk). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Quisqualic Acid (Quisqualate, Alpha-Amino-3,5-Dioxo-1,2,4- Oxadiazolidine-2-Propanoic Acid), PDB code: 2jbk:

Chlorine binding site 1 out of 1 in 2jbk

Go back to Chlorine Binding Sites List in 2jbk
Chlorine binding site 1 out of 1 in the Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Quisqualic Acid (Quisqualate, Alpha-Amino-3,5-Dioxo-1,2,4- Oxadiazolidine-2-Propanoic Acid)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Quisqualic Acid (Quisqualate, Alpha-Amino-3,5-Dioxo-1,2,4- Oxadiazolidine-2-Propanoic Acid) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl804

b:35.0
occ:1.00
 O A:HOH2011 2.8 35.0 1.0
ND2 A:ASN451 3.3 35.0 1.0
N A:ASP453 3.4 35.0 1.0
NE A:ARG534 3.5 35.0 1.0
NH2 A:ARG534 3.7 35.0 1.0
CB A:ARG534 3.8 35.0 1.0
CB A:ASN451 3.9 35.0 1.0
NH2 A:ARG580 3.9 35.0 1.0
CB A:ASP453 4.0 35.0 1.0
CG A:ASN451 4.0 35.0 1.0
C A:ASN451 4.0 35.0 1.0
CZ A:ARG534 4.0 35.0 1.0
O A:ASN451 4.1 35.0 1.0
CA A:ASP453 4.1 35.0 1.0
N A:ALA452 4.1 35.0 1.0
CA A:ALA452 4.3 35.0 1.0
C A:ALA452 4.3 35.0 1.0
C A:ASP453 4.4 35.0 1.0
CG A:ARG534 4.5 35.0 1.0
CD A:ARG534 4.5 35.0 1.0
O A:ASP453 4.6 35.0 1.0
O A:SER454 4.6 35.0 1.0
CA A:ASN451 4.7 35.0 1.0
CZ A:ARG580 4.7 35.0 1.0
CA A:ARG534 4.9 35.0 1.0
N A:SER454 5.0 35.0 1.0
O A:ALA535 5.0 35.0 1.0

Reference:

J.R.Mesters, K.Henning, R.Hilgenfeld. Human Glutamate Carboxypeptidase II Inhibition: Structures of Gcpii in Complex with Two Potent Inhibitors, Quisqualate and 2-Pmpa. Acta Crystallogr.,Sect.D V. 63 508 2007.
ISSN: ISSN 0907-4449
PubMed: 17372356
DOI: 10.1107/S090744490700902X
Page generated: Thu Jul 10 23:06:25 2025

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