Chlorine in PDB 2oyu: Indomethacin-(S)-Alpha-Ethyl-Ethanolamide Bound to Cyclooxygenase-1

Enzymatic activity of Indomethacin-(S)-Alpha-Ethyl-Ethanolamide Bound to Cyclooxygenase-1

All present enzymatic activity of Indomethacin-(S)-Alpha-Ethyl-Ethanolamide Bound to Cyclooxygenase-1:
1.14.99.1;

Protein crystallography data

The structure of Indomethacin-(S)-Alpha-Ethyl-Ethanolamide Bound to Cyclooxygenase-1, PDB code: 2oyu was solved by C.A.Harman, R.M.Garavito, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	30.00 / 2.70
*Space group*	P 6₅ 2 2
*Cell size a, b, c (Å), α, β, γ (°)*	181.410, 181.410, 103.398, 90.00, 90.00, 120.00
*R / R_free (%)*	24.1 / 29.2

Other elements in 2oyu:

The structure of Indomethacin-(S)-Alpha-Ethyl-Ethanolamide Bound to Cyclooxygenase-1 also contains other interesting chemical elements:

Iron

(Fe)

1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Indomethacin-(S)-Alpha-Ethyl-Ethanolamide Bound to Cyclooxygenase-1 (pdb code 2oyu). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Indomethacin-(S)-Alpha-Ethyl-Ethanolamide Bound to Cyclooxygenase-1, PDB code: 2oyu:

Chlorine binding site 1 out of 1 in 2oyu

Go back to

Chlorine Binding Sites List in 2oyu

Chlorine binding site 1 out of 1 in the Indomethacin-(S)-Alpha-Ethyl-Ethanolamide Bound to Cyclooxygenase-1

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Indomethacin-(S)-Alpha-Ethyl-Ethanolamide Bound to Cyclooxygenase-1 within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
P:Cl700 b:60.3 occ:1.00	CL	P:IMS700	0.0	60.3	1.0
	C13	P:IMS700	1.5	60.4	1.0
	C12	P:IMS700	2.5	60.4	1.0
	C14	P:IMS700	2.5	59.8	1.0
	CE	P:MET113	3.1	53.4	1.0
	CD2	P:LEU359	3.2	50.2	1.0
	SD	P:MET113	3.3	58.0	1.0
	CB	P:LEU359	3.4	50.2	1.0
	CG	P:LEU359	3.5	49.9	1.0
	CD1	P:LEU359	3.6	50.7	1.0
	C11	P:IMS700	3.8	59.6	1.0
	C15	P:IMS700	3.8	59.8	1.0
	CA	P:LEU359	4.2	50.4	1.0
	CG1	P:VAL116	4.2	46.2	1.0
	C10	P:IMS700	4.2	59.7	1.0
	CG2	P:ILE345	4.7	46.1	1.0
	N	P:LYS360	4.8	49.9	1.0
	CD2	P:LEU531	5.0	46.8	1.0

Reference:

C.A.Harman, M.V.Turman, K.R.Kozak, L.J.Marnett, W.L.Smith, R.M.Garavito. Structural Basis of Enantioselective Inhibition of Cyclooxygenase-1 By S-Alpha-Substituted Indomethacin Ethanolamides. J.Biol.Chem. V. 282 28096 2007.
ISSN: ISSN 0021-9258
PubMed: 17656360
DOI: 10.1074/JBC.M701335200

Page generated: Thu Jul 10 23:42:33 2025

Last articles

Fe in 2YXO
Fe in 2YRS
Fe in 2YXC
Fe in 2YNM
Fe in 2YVJ
Fe in 2YP1
Fe in 2YU2
Fe in 2YU1
Fe in 2YQB
Fe in 2YOO

	© Copyright 2008-2020 by atomistry.com
Home \| Site Map \| Copyright \| Contact us \| Privacy