Chlorine in PDB 2rfs: X-Ray Structure of SU11274 Bound to C-Met

All present enzymatic activity of X-Ray Structure of SU11274 Bound to C-Met:
2.7.10.1;

The structure of X-Ray Structure of SU11274 Bound to C-Met, PDB code: 2rfs was solved by S.F.Bellon, P.Kaplan-Lefko, Y.Yang, Y.Zhang, J.Moriguchi, I.Dussault, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	25.28 / 2.20
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	42.104, 43.441, 158.072, 90.00, 90.00, 90.00
R / Rfree (%)	22.4 / 26.2

The binding sites of Chlorine atom in the X-Ray Structure of SU11274 Bound to C-Met (pdb code 2rfs). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the X-Ray Structure of SU11274 Bound to C-Met, PDB code: 2rfs:

Chlorine binding site 1 out of 1 in the X-Ray Structure of SU11274 Bound to C-Met


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of X-Ray Structure of SU11274 Bound to C-Met within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1 b:52.1 occ:1.00 CLBM A:AM81 0.0 52.1 1.0 CBA A:AM81 1.7 51.5 1.0 CAZ A:AM81 2.7 51.2 1.0 CBB A:AM81 2.7 51.4 1.0 CG1 A:VAL1092 3.2 50.4 1.0 CA A:GLY1085 3.5 58.8 1.0 CG2 A:ILE1084 3.7 58.3 1.0 N A:GLY1085 3.7 58.7 1.0 C A:ILE1084 3.9 58.7 1.0 O A:ILE1084 3.9 58.6 1.0 CAY A:AM81 4.0 51.2 1.0 CBC A:AM81 4.0 51.6 1.0 CAE A:AM81 4.1 51.6 1.0 CD1 A:TYR1230 4.2 44.5 1.0 C A:GLY1085 4.3 58.9 1.0 CE1 A:TYR1230 4.3 44.0 1.0 CAJ A:AM81 4.4 50.2 1.0 CBD A:AM81 4.5 51.3 1.0 CB A:ILE1084 4.5 58.6 1.0 O A:GLY1085 4.6 58.9 1.0 CB A:VAL1092 4.7 50.3 1.0 CG A:TYR1230 4.8 44.4 1.0 CA A:ILE1084 4.9 58.6 1.0 CAM A:AM81 4.9 49.1 1.0 CAD A:AM81 4.9 51.5 1.0 CZ A:TYR1230 4.9 44.2 1.0

S.F.Bellon, P.Kaplan-Lefko, Y.Yang, Y.Zhang, J.Moriguchi, K.Rex, C.W.Johnson, P.E.Rose, A.M.Long, A.B.O'connor, Y.Gu, A.Coxon, T.S.Kim, A.Tasker, T.L.Burgess, I.Dussault. C-Met Inhibitors with Novel Binding Mode Show Activity Against Several Hereditary Papillary Renal Cell Carcinoma-Related Mutations. J.Biol.Chem. V. 283 2675 2008.
ISSN: ISSN 0021-9258
PubMed: 18055465
DOI: 10.1074/JBC.M705774200