Atomistry » Chlorine » PDB 2rha-2uxn » 2rl5
Atomistry »
  Chlorine »
    PDB 2rha-2uxn »
      2rl5 »

Chlorine in PDB 2rl5: Crystal Structure of the VEGFR2 Kinase Domain in Complex with A 2,3- Dihydro-1,4-Benzoxazine Inhibitor

Enzymatic activity of Crystal Structure of the VEGFR2 Kinase Domain in Complex with A 2,3- Dihydro-1,4-Benzoxazine Inhibitor

All present enzymatic activity of Crystal Structure of the VEGFR2 Kinase Domain in Complex with A 2,3- Dihydro-1,4-Benzoxazine Inhibitor:
2.7.10.1;

Protein crystallography data

The structure of Crystal Structure of the VEGFR2 Kinase Domain in Complex with A 2,3- Dihydro-1,4-Benzoxazine Inhibitor, PDB code: 2rl5 was solved by D.A.Whittington, A.M.Long, P.Rose, H.Zhao, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 2.65
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 66.760, 139.774, 57.550, 90.00, 90.00, 90.00
R / Rfree (%) 19.9 / 23.3

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of the VEGFR2 Kinase Domain in Complex with A 2,3- Dihydro-1,4-Benzoxazine Inhibitor (pdb code 2rl5). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of the VEGFR2 Kinase Domain in Complex with A 2,3- Dihydro-1,4-Benzoxazine Inhibitor, PDB code: 2rl5:

Chlorine binding site 1 out of 1 in 2rl5

Go back to Chlorine Binding Sites List in 2rl5
Chlorine binding site 1 out of 1 in the Crystal Structure of the VEGFR2 Kinase Domain in Complex with A 2,3- Dihydro-1,4-Benzoxazine Inhibitor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the VEGFR2 Kinase Domain in Complex with A 2,3- Dihydro-1,4-Benzoxazine Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl501

b:12.2
occ:1.00
CL48 A:2RL501 0.0 12.2 1.0
C41 A:2RL501 1.7 14.8 1.0
C42 A:2RL501 2.7 17.1 1.0
C40 A:2RL501 2.7 16.9 1.0
CD1 A:LEU1019 3.6 16.4 1.0
CD1 A:ILE892 3.8 16.3 1.0
CD2 A:LEU1019 3.9 12.9 1.0
C39 A:2RL501 4.0 15.3 1.0
C43 A:2RL501 4.0 18.4 1.0
O A:HOH110 4.0 38.0 1.0
CD2 A:HIS1026 4.1 19.6 1.0
CG A:LEU1019 4.4 14.4 1.0
C38 A:2RL501 4.6 18.4 1.0
CA A:HIS1026 4.8 26.4 1.0
CG A:HIS1026 4.8 21.2 1.0
NE2 A:HIS1026 4.9 19.2 1.0
CB A:HIS1026 5.0 23.2 1.0

Reference:

D.S.La, J.Belzile, J.V.Bready, A.Coxon, T.Demelfi, N.Doerr, J.Estrada, J.C.Flynn, S.R.Flynn, R.F.Graceffa, S.P.Harriman, J.F.Larrow, A.M.Long, M.W.Martin, M.J.Morrison, V.F.Patel, P.M.Roveto, L.Wang, M.M.Weiss, D.A.Whittington, Y.Teffera, Z.Zhao, A.J.Polverino, J.C.Harmange. Novel 2,3-Dihydro-1,4-Benzoxazines As Potent and Orally Bioavailable Inhibitors of Tumor-Driven Angiogenesis. J.Med.Chem. V. 51 1695 2008.
ISSN: ISSN 0022-2623
PubMed: 18311900
DOI: 10.1021/JM701129J
Page generated: Sat Jul 20 11:21:43 2024

Last articles

Zn in 9MJ5
Zn in 9HNW
Zn in 9G0L
Zn in 9FNE
Zn in 9DZN
Zn in 9E0I
Zn in 9D32
Zn in 9DAK
Zn in 8ZXC
Zn in 8ZUF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy