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Atomistry » Chlorine » PDB 2rha-2uxn » 2uw5 » |
Chlorine in PDB 2uw5: Structure of Pka-Pkb Chimera Complexed with (R)-2-(4- Chloro-Phenyl)-2-(4-1H-Pyrazol-4-Yl)-Phenyl)-EthylamineEnzymatic activity of Structure of Pka-Pkb Chimera Complexed with (R)-2-(4- Chloro-Phenyl)-2-(4-1H-Pyrazol-4-Yl)-Phenyl)-Ethylamine
All present enzymatic activity of Structure of Pka-Pkb Chimera Complexed with (R)-2-(4- Chloro-Phenyl)-2-(4-1H-Pyrazol-4-Yl)-Phenyl)-Ethylamine:
2.7.11.11; Protein crystallography data
The structure of Structure of Pka-Pkb Chimera Complexed with (R)-2-(4- Chloro-Phenyl)-2-(4-1H-Pyrazol-4-Yl)-Phenyl)-Ethylamine, PDB code: 2uw5
was solved by
T.G.Davies,
G.Saxty,
S.J.Woodhead,
V.Berdini,
M.L.Verdonk,
P.G.Wyatt,
R.G.Boyle,
D.Barford,
R.Downham,
M.D.Garrett,
R.A.Carr,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Structure of Pka-Pkb Chimera Complexed with (R)-2-(4- Chloro-Phenyl)-2-(4-1H-Pyrazol-4-Yl)-Phenyl)-Ethylamine
(pdb code 2uw5). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structure of Pka-Pkb Chimera Complexed with (R)-2-(4- Chloro-Phenyl)-2-(4-1H-Pyrazol-4-Yl)-Phenyl)-Ethylamine, PDB code: 2uw5: Chlorine binding site 1 out of 1 in 2uw5Go back to![]() ![]()
Chlorine binding site 1 out
of 1 in the Structure of Pka-Pkb Chimera Complexed with (R)-2-(4- Chloro-Phenyl)-2-(4-1H-Pyrazol-4-Yl)-Phenyl)-Ethylamine
![]() Mono view ![]() Stereo pair view
Reference:
G.Saxty,
S.J.Woodhead,
V.Berdini,
T.G.Davies,
M.L.Verdonk,
P.G.Wyatt,
R.G.Boyle,
D.Barford,
R.Downham,
M.D.Garrett,
R.A.Carr.
Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery J.Med.Chem. V. 50 2293 2007.
Page generated: Sat Jul 20 11:24:49 2024
ISSN: ISSN 0022-2623 PubMed: 17451234 DOI: 10.1021/JM070091B |
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