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Chlorine in PDB 2v2h: The A178L Mutation in the C-Terminal Hinge of the Flexible Loop-6 of Triosephosphate Isomerase (Tim) Induces A More Closed Conformation of This Hinge Region in Dimeric and Monomeric Tim

Enzymatic activity of The A178L Mutation in the C-Terminal Hinge of the Flexible Loop-6 of Triosephosphate Isomerase (Tim) Induces A More Closed Conformation of This Hinge Region in Dimeric and Monomeric Tim

All present enzymatic activity of The A178L Mutation in the C-Terminal Hinge of the Flexible Loop-6 of Triosephosphate Isomerase (Tim) Induces A More Closed Conformation of This Hinge Region in Dimeric and Monomeric Tim:
5.3.1.1;

Protein crystallography data

The structure of The A178L Mutation in the C-Terminal Hinge of the Flexible Loop-6 of Triosephosphate Isomerase (Tim) Induces A More Closed Conformation of This Hinge Region in Dimeric and Monomeric Tim, PDB code: 2v2h was solved by M.Alahuhta, M.G.Casteleijn, P.Neubauer, R.K.Wierenga, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.00 / 1.18
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 68.260, 117.990, 81.770, 90.00, 95.84, 90.00
R / Rfree (%) 13.9 / 18.7

Chlorine Binding Sites:

The binding sites of Chlorine atom in the The A178L Mutation in the C-Terminal Hinge of the Flexible Loop-6 of Triosephosphate Isomerase (Tim) Induces A More Closed Conformation of This Hinge Region in Dimeric and Monomeric Tim (pdb code 2v2h). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the The A178L Mutation in the C-Terminal Hinge of the Flexible Loop-6 of Triosephosphate Isomerase (Tim) Induces A More Closed Conformation of This Hinge Region in Dimeric and Monomeric Tim, PDB code: 2v2h:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in 2v2h

Go back to Chlorine Binding Sites List in 2v2h
Chlorine binding site 1 out of 3 in the The A178L Mutation in the C-Terminal Hinge of the Flexible Loop-6 of Triosephosphate Isomerase (Tim) Induces A More Closed Conformation of This Hinge Region in Dimeric and Monomeric Tim


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of The A178L Mutation in the C-Terminal Hinge of the Flexible Loop-6 of Triosephosphate Isomerase (Tim) Induces A More Closed Conformation of This Hinge Region in Dimeric and Monomeric Tim within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1252

b:10.6
occ:1.00
N A:LEU131 3.2 9.6 1.0
N A:TRP170 3.7 10.1 1.0
CB A:TRP170 3.8 11.7 1.0
CG1 A:VAL169 3.8 12.6 1.0
CA A:TRP170 3.8 10.1 1.0
CB A:LEU131 3.8 12.1 1.0
CA A:THR130 3.9 9.8 1.0
CB A:THR130 3.9 9.4 1.0
CB A:VAL169 4.0 11.2 1.0
C A:THR130 4.1 9.7 1.0
C A:VAL169 4.1 9.7 1.0
CA A:LEU131 4.1 9.4 1.0
O A:VAL169 4.5 10.8 1.0
CG2 A:THR130 4.6 10.2 1.0
OE1 A:GLN132 4.6 11.6 1.0
CA A:VAL169 4.6 10.1 1.0
CG A:TRP170 4.7 10.8 1.0
CD1 A:TRP170 4.8 10.1 1.0

Chlorine binding site 2 out of 3 in 2v2h

Go back to Chlorine Binding Sites List in 2v2h
Chlorine binding site 2 out of 3 in the The A178L Mutation in the C-Terminal Hinge of the Flexible Loop-6 of Triosephosphate Isomerase (Tim) Induces A More Closed Conformation of This Hinge Region in Dimeric and Monomeric Tim


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of The A178L Mutation in the C-Terminal Hinge of the Flexible Loop-6 of Triosephosphate Isomerase (Tim) Induces A More Closed Conformation of This Hinge Region in Dimeric and Monomeric Tim within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl1252

b:8.4
occ:1.00
N B:LEU131 3.3 7.6 1.0
N B:TRP170 3.7 7.1 1.0
CB B:TRP170 3.7 9.5 1.0
CA B:TRP170 3.8 8.0 1.0
CB B:LEU131 3.8 10.0 1.0
CA B:THR130 3.8 7.0 1.0
CG1 B:VAL169 3.8 12.5 1.0
CB B:VAL169 3.9 8.8 1.0
CB B:THR130 4.0 7.5 1.0
C B:VAL169 4.0 6.6 1.0
C B:THR130 4.0 7.3 1.0
CA B:LEU131 4.1 8.5 1.0
O B:VAL169 4.5 8.2 1.0
CA B:VAL169 4.6 7.2 1.0
CG2 B:THR130 4.6 8.5 1.0
OE1 B:GLN132 4.7 9.7 1.0
CG B:TRP170 4.7 8.7 1.0
CD1 B:TRP170 4.8 7.8 1.0

Chlorine binding site 3 out of 3 in 2v2h

Go back to Chlorine Binding Sites List in 2v2h
Chlorine binding site 3 out of 3 in the The A178L Mutation in the C-Terminal Hinge of the Flexible Loop-6 of Triosephosphate Isomerase (Tim) Induces A More Closed Conformation of This Hinge Region in Dimeric and Monomeric Tim


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of The A178L Mutation in the C-Terminal Hinge of the Flexible Loop-6 of Triosephosphate Isomerase (Tim) Induces A More Closed Conformation of This Hinge Region in Dimeric and Monomeric Tim within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl1252

b:9.0
occ:1.00
N C:LEU131 3.2 8.0 1.0
N C:TRP170 3.7 7.7 1.0
CB C:TRP170 3.7 10.3 1.0
CB C:LEU131 3.7 10.4 1.0
CA C:TRP170 3.8 8.7 1.0
CG1 C:VAL169 3.8 11.4 1.0
CA C:THR130 3.9 7.4 1.0
CB C:THR130 4.0 8.0 1.0
CB C:VAL169 4.0 9.0 1.0
C C:THR130 4.0 8.4 1.0
C C:VAL169 4.1 7.9 1.0
CA C:LEU131 4.1 8.2 1.0
O C:VAL169 4.6 8.9 1.0
CG2 C:THR130 4.6 9.6 1.0
CA C:VAL169 4.7 8.6 1.0
OE1 C:GLN132 4.7 9.9 1.0
CG C:TRP170 4.7 9.1 1.0
CD1 C:TRP170 4.9 9.5 1.0

Reference:

M.Alahuhta, M.G.Casteleijn, P.Neubauer, R.K.Wierenga. Structural Studies Show That the A178L Mutation in the C-Terminal Hinge of the Catalytic Loop-6 of Triosephosphate Isomerase (Tim) Induces A Closed-Like Conformation in Dimeric and Monomeric Tim. Acta Crystallogr.,Sect.D V. 64 178 2008.
ISSN: ISSN 0907-4449
PubMed: 18219118
DOI: 10.1107/S0907444907059021
Page generated: Fri Jul 11 00:38:09 2025

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