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Chlorine in PDB 2v4m: The Isomerase Domain of Human Glutamine-Fructose-6-Phosphate Transaminase 1 (GFPT1) in Complex with Fructose 6-Phosphate

Enzymatic activity of The Isomerase Domain of Human Glutamine-Fructose-6-Phosphate Transaminase 1 (GFPT1) in Complex with Fructose 6-Phosphate

All present enzymatic activity of The Isomerase Domain of Human Glutamine-Fructose-6-Phosphate Transaminase 1 (GFPT1) in Complex with Fructose 6-Phosphate:
2.6.1.16;

Protein crystallography data

The structure of The Isomerase Domain of Human Glutamine-Fructose-6-Phosphate Transaminase 1 (GFPT1) in Complex with Fructose 6-Phosphate, PDB code: 2v4m was solved by M.Moche, L.Lehtio, J.Andersson, C.H.Arrowsmith, H.Berglund, R.Collins, L.G.Dahlgren, A.M.Edwards, S.Flodin, A.Flores, S.Graslund, M.Hammarstrom, A.Johansson, I.Johansson, T.Karlberg, T.Kotenyova, M.E.Nilsson, T.Nyman, C.Persson, J.Sagemark, S.Svensson, H.Schueler, A.G.Thorsell, L.Tresaugues, J.Uppenberg, S.Van Den Berg, M.Welin, M.Wisniewska, J.Weigelt, P.Nordlund, M.Wikstrom, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 54.89 / 2.29
Space group H 3
Cell size a, b, c (Å), α, β, γ (°) 178.824, 178.824, 157.113, 90.00, 90.00, 120.00
R / Rfree (%) 16.7 / 18.5

Chlorine Binding Sites:

The binding sites of Chlorine atom in the The Isomerase Domain of Human Glutamine-Fructose-6-Phosphate Transaminase 1 (GFPT1) in Complex with Fructose 6-Phosphate (pdb code 2v4m). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the The Isomerase Domain of Human Glutamine-Fructose-6-Phosphate Transaminase 1 (GFPT1) in Complex with Fructose 6-Phosphate, PDB code: 2v4m:

Chlorine binding site 1 out of 1 in 2v4m

Go back to Chlorine Binding Sites List in 2v4m
Chlorine binding site 1 out of 1 in the The Isomerase Domain of Human Glutamine-Fructose-6-Phosphate Transaminase 1 (GFPT1) in Complex with Fructose 6-Phosphate


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of The Isomerase Domain of Human Glutamine-Fructose-6-Phosphate Transaminase 1 (GFPT1) in Complex with Fructose 6-Phosphate within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl1691

b:45.1
occ:1.00
 N C:GLY373 3.0 37.5 1.0
N C:GLY372 3.3 37.5 1.0
NH2 C:ARG361 3.5 33.4 1.0
C C:LEU371 3.6 37.7 1.0
CA C:LEU371 3.7 37.6 1.0
NE C:ARG361 3.7 33.7 1.0
CA C:GLY373 3.7 37.8 1.0
CB C:LEU371 3.8 37.2 1.0
CZ C:ARG361 4.0 33.7 1.0
C C:GLY372 4.0 37.3 1.0
CA C:GLY372 4.1 37.5 1.0
CG1 C:VAL480 4.1 35.6 1.0
CD2 C:LEU371 4.3 33.6 1.0
CA C:VAL480 4.3 35.9 1.0
O C:LEU371 4.3 37.2 1.0
O C:GLY479 4.4 36.4 1.0
CG2 C:VAL480 4.5 35.8 1.0
CB C:VAL480 4.5 36.0 1.0
CG C:LEU371 4.7 36.4 1.0
C C:GLY373 4.8 38.1 1.0
CD C:ARG361 4.8 32.8 1.0
N C:LEU374 4.8 38.9 1.0
N C:HIS481 5.0 36.7 1.0

Reference:

M.Moche, L.Lehtio, J.Andersson, C.H.Arrowsmith, H.Berglund, R.Collins, L.G.Dahlgren, A.M.Edwards, S.Flodin, A.Flores, S.Graslund, M.Hammarstrom, A.Johansson, I.Johansson, T.Karlberg, T.Kotenyova, M.E.Nilsson, T.Nyman, C.Persson, J.Sagemark, S.Svensson, H.Schueler, A.G.Thorsell, L.Tresaugues, J.Uppenberg, S.Van Den Berg, M.Welin, M.Wisniewska, J.Weigelt, P.Nordlund, M.Wikstrom. The Isomerase Domain of Human GFPT1 in Complex with Fructose 6-Phosphate To Be Published.
Page generated: Fri Jul 11 00:39:56 2025

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