Atomistry » Chlorine » PDB 2wjq-2wpr » 2wo6
Atomistry »
  Chlorine »
    PDB 2wjq-2wpr »
      2wo6 »

Chlorine in PDB 2wo6: Human Dual-Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A in Complex with A Consensus Substrate Peptide

Enzymatic activity of Human Dual-Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A in Complex with A Consensus Substrate Peptide

All present enzymatic activity of Human Dual-Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A in Complex with A Consensus Substrate Peptide:
2.7.12.1;

Protein crystallography data

The structure of Human Dual-Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A in Complex with A Consensus Substrate Peptide, PDB code: 2wo6 was solved by A.K.Roos, M.Soundararajan, J.M.Elkins, O.Fedorov, J.Eswaran, C.Phillips, A.C.W.Pike, E.Ugochukwu, J.R.C.Muniz, N.Burgess-Brown, F.Von Delft, C.H.Arrowsmith, M.Wikstrom, A.Edwards, C.Bountra, S.Knapp, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 40.00 / 2.50
Space group P 65
Cell size a, b, c (Å), α, β, γ (°) 168.430, 168.430, 62.420, 90.00, 90.00, 120.00
R / Rfree (%) 18.8 / 22.9

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Human Dual-Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A in Complex with A Consensus Substrate Peptide (pdb code 2wo6). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Human Dual-Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A in Complex with A Consensus Substrate Peptide, PDB code: 2wo6:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in 2wo6

Go back to Chlorine Binding Sites List in 2wo6
Chlorine binding site 1 out of 3 in the Human Dual-Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A in Complex with A Consensus Substrate Peptide


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Dual-Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A in Complex with A Consensus Substrate Peptide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl600

b:38.9
occ:1.00
 CL1 A:D15600 0.0 38.9 1.0
CAY A:D15600 1.8 31.6 1.0
CAI A:D15600 2.7 28.0 1.0
CAO A:D15600 2.8 31.2 1.0
N A:GLY171 3.4 23.7 1.0
C A:GLY171 3.4 23.4 1.0
CA A:GLY171 3.6 23.7 1.0
O A:GLY171 3.7 23.6 1.0
N A:GLN172 3.7 23.0 1.0
CG A:LYS188 3.7 24.0 1.0
C A:PHE170 3.8 24.1 1.0
CE A:LYS188 3.8 29.5 1.0
CAH A:D15600 4.0 29.5 1.0
CBB A:D15600 4.1 30.2 1.0
O A:HOH2023 4.1 34.5 1.0
CD A:LYS188 4.2 26.5 1.0
CB A:PHE170 4.2 24.8 1.0
CA A:PHE170 4.4 24.6 1.0
O A:PHE170 4.4 23.7 1.0
CA A:GLN172 4.4 22.6 1.0
O A:HOH2032 4.5 25.7 1.0
C A:GLN172 4.6 22.1 1.0
CAL A:D15600 4.6 27.9 1.0
N A:PHE170 4.6 24.5 1.0
O A:GLN172 4.6 22.4 1.0
CG2 A:VAL173 4.8 19.5 1.0
CA A:GLY168 4.8 26.1 1.0
CD1 A:ILE190 4.9 17.7 1.0
N A:GLY168 5.0 26.0 1.0

Chlorine binding site 2 out of 3 in 2wo6

Go back to Chlorine Binding Sites List in 2wo6
Chlorine binding site 2 out of 3 in the Human Dual-Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A in Complex with A Consensus Substrate Peptide


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Human Dual-Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A in Complex with A Consensus Substrate Peptide within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl600

b:50.6
occ:1.00
 CL1 B:D15600 0.0 50.6 1.0
CAY B:D15600 1.8 45.4 1.0
CAI B:D15600 2.7 43.9 1.0
CAO B:D15600 2.8 44.8 1.0
O B:HOH2005 3.5 41.6 1.0
CE B:LYS188 3.6 29.1 1.0
N B:GLY171 3.7 23.9 1.0
C B:GLY171 3.7 23.4 1.0
O B:GLY171 3.9 23.4 1.0
CG B:LYS188 3.9 24.3 1.0
CA B:GLY171 4.0 23.4 1.0
CAH B:D15600 4.0 44.1 1.0
N B:GLN172 4.1 22.9 1.0
CBB B:D15600 4.1 44.9 1.0
C B:PHE170 4.1 24.3 1.0
CB B:PHE170 4.2 25.2 1.0
CD B:LYS188 4.2 26.6 1.0
CA B:PHE170 4.5 24.7 1.0
CAL B:D15600 4.6 43.4 1.0
CG2 B:VAL173 4.6 19.4 1.0
N B:PHE170 4.6 25.0 1.0
O B:GLN172 4.6 22.4 1.0
CA B:GLN172 4.7 22.5 1.0
C B:GLN172 4.7 22.1 1.0
CA B:GLY168 4.8 26.4 1.0
O B:PHE170 4.8 24.3 1.0
NZ B:LYS188 4.8 30.6 1.0

Chlorine binding site 3 out of 3 in 2wo6

Go back to Chlorine Binding Sites List in 2wo6
Chlorine binding site 3 out of 3 in the Human Dual-Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A in Complex with A Consensus Substrate Peptide


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Human Dual-Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A in Complex with A Consensus Substrate Peptide within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl700

b:47.3
occ:1.00
 O B:HOH2043 2.8 28.6 1.0
NZ B:LYS188 2.8 30.6 1.0
CE B:LYS188 2.9 29.1 1.0
NAT B:D15600 3.2 40.4 1.0
CAM B:D15600 3.6 38.0 1.0
CA B:ASP307 3.8 21.3 1.0
CB B:ASP307 3.8 22.2 1.0
N B:ASP307 3.9 20.9 1.0
CAZ B:D15600 3.9 37.9 1.0
CG B:ASP307 3.9 23.3 1.0
CAO B:D15600 3.9 44.8 1.0
CD B:LYS188 4.0 26.6 1.0
CAR B:D15600 4.1 45.9 1.0
CAX B:D15600 4.1 45.4 1.0
OD2 B:ASP307 4.2 26.2 1.0
CBF B:D15600 4.4 45.4 1.0
OD1 B:ASP307 4.4 24.1 1.0
O B:HOH2012 4.4 28.3 1.0
CBB B:D15600 4.5 44.9 1.0
CB B:VAL306 4.6 21.0 1.0
CG B:LYS188 4.6 24.3 1.0
CE2 B:PHE238 4.6 22.7 1.0
OE2 B:GLU203 4.7 23.9 1.0
CG2 B:VAL306 4.8 20.9 1.0
CAN B:D15600 4.8 36.5 1.0
CZ B:PHE238 4.9 23.4 1.0
C B:VAL306 4.9 20.3 1.0
CAY B:D15600 5.0 45.4 1.0

Reference:

M.Soundararajan, A.K.Roos, P.Savitsky, P.Filippakopoulos, A.N.Kettenbach, J.V.Olsen, S.A.Gerber, J.Eswaran, S.Knapp, J.M.Elkins. Structures of Down Syndrome Kinases, Dyrks, Reveal Mechanisms of Kinase Activation and Substrate Recognition. Structure V. 21 986 2013.
ISSN: ISSN 0969-2126
PubMed: 23665168
DOI: 10.1016/J.STR.2013.03.012
Page generated: Fri Jul 11 01:31:34 2025

Last articles

Fe in 2YXO
Fe in 2YRS
Fe in 2YXC
Fe in 2YNM
Fe in 2YVJ
Fe in 2YP1
Fe in 2YU2
Fe in 2YU1
Fe in 2YQB
Fe in 2YOO
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy