Chlorine »
PDB 2wps-2wzc »
2wsa »
Chlorine in PDB 2wsa: Crystal Structure of Leishmania Major N- Myristoyltransferase (Nmt) with Bound Myristoyl-Coa and A Pyrazole Sulphonamide Ligand (DDD85646)
Enzymatic activity of Crystal Structure of Leishmania Major N- Myristoyltransferase (Nmt) with Bound Myristoyl-Coa and A Pyrazole Sulphonamide Ligand (DDD85646)
All present enzymatic activity of Crystal Structure of Leishmania Major N- Myristoyltransferase (Nmt) with Bound Myristoyl-Coa and A Pyrazole Sulphonamide Ligand (DDD85646):
2.3.1.97;
2.3.1.97;
Protein crystallography data
The structure of Crystal Structure of Leishmania Major N- Myristoyltransferase (Nmt) with Bound Myristoyl-Coa and A Pyrazole Sulphonamide Ligand (DDD85646), PDB code: 2wsa
was solved by
D.A.Robinson,
S.Brand,
A.H.Fairlamb,
M.A.J.Ferguson,
J.A.Frearson,
P.G.Wyatt,
Structural Genomics Consortium(Sgc),
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 20.00 / 1.60 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 47.510, 90.317, 52.972, 90.00, 112.27, 90.00 |
| R / Rfree (%) | 17.6 / 21.296 |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Leishmania Major N- Myristoyltransferase (Nmt) with Bound Myristoyl-Coa and A Pyrazole Sulphonamide Ligand (DDD85646)
(pdb code 2wsa). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Leishmania Major N- Myristoyltransferase (Nmt) with Bound Myristoyl-Coa and A Pyrazole Sulphonamide Ligand (DDD85646), PDB code: 2wsa:
Jump to Chlorine binding site number: 1; 2;
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Leishmania Major N- Myristoyltransferase (Nmt) with Bound Myristoyl-Coa and A Pyrazole Sulphonamide Ligand (DDD85646), PDB code: 2wsa:
Jump to Chlorine binding site number: 1; 2;
Chlorine binding site 1 out of 2 in 2wsa
Go back to
Chlorine Binding Sites List in 2wsa
Chlorine binding site 1 out
of 2 in the Crystal Structure of Leishmania Major N- Myristoyltransferase (Nmt) with Bound Myristoyl-Coa and A Pyrazole Sulphonamide Ligand (DDD85646)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of Leishmania Major N- Myristoyltransferase (Nmt) with Bound Myristoyl-Coa and A Pyrazole Sulphonamide Ligand (DDD85646) within 5.0Å range:
|
Chlorine binding site 2 out of 2 in 2wsa
Go back to
Chlorine Binding Sites List in 2wsa
Chlorine binding site 2 out
of 2 in the Crystal Structure of Leishmania Major N- Myristoyltransferase (Nmt) with Bound Myristoyl-Coa and A Pyrazole Sulphonamide Ligand (DDD85646)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Crystal Structure of Leishmania Major N- Myristoyltransferase (Nmt) with Bound Myristoyl-Coa and A Pyrazole Sulphonamide Ligand (DDD85646) within 5.0Å range:
|
Reference:
J.A.Frearson,
S.Brand,
L.A.T.Cleghorn,
S.Mcelroy,
O.Smid,
L.Stojanovski,
L.Torrie,
D.A.Robinson,
I.Hallyburton,
M.L.Guther,
H.P.Price,
C.P.Mpamhanga,
J.A.Brannigan,
M.Hodgkinson,
O.Raimi,
D.M.F.Van Aalten,
R.Brenk,
I.H.Gilbert,
K.D.Read,
A.H.Fairlamb,
M.A.J.Ferguson,
D.F.Smith,
P.G.Wyatt.
N-Myristoyltransferase Inhibitors As New Leads to Treat Sleeping Sickness. Nature V. 464 728 2010.
ISSN: ISSN 0028-0836
PubMed: 20360736
DOI: 10.1038/NATURE08893
Page generated: Sat Jul 20 13:16:59 2024
ISSN: ISSN 0028-0836
PubMed: 20360736
DOI: 10.1038/NATURE08893
Last articles
Zn in 9MJ5Zn in 9HNW
Zn in 9G0L
Zn in 9FNE
Zn in 9DZN
Zn in 9E0I
Zn in 9D32
Zn in 9DAK
Zn in 8ZXC
Zn in 8ZUF
