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Chlorine in PDB 2wzb: The Catalytically Active Fully Closed Conformation of Human Phosphoglycerate Kinase in Complex with Adp, 3PG and Magnesium Trifluoride

Enzymatic activity of The Catalytically Active Fully Closed Conformation of Human Phosphoglycerate Kinase in Complex with Adp, 3PG and Magnesium Trifluoride

All present enzymatic activity of The Catalytically Active Fully Closed Conformation of Human Phosphoglycerate Kinase in Complex with Adp, 3PG and Magnesium Trifluoride:
2.7.2.3;

Protein crystallography data

The structure of The Catalytically Active Fully Closed Conformation of Human Phosphoglycerate Kinase in Complex with Adp, 3PG and Magnesium Trifluoride, PDB code: 2wzb was solved by M.W.Bowler, M.J.Cliff, J.P.M.Marston, N.J.Baxter, A.M.H.Hownslow, A.V.Varga, J.Szabo, M.Vas, G.M.Blackburn, J.P.Waltho, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 1.47
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 39.430, 92.180, 109.000, 90.00, 90.00, 90.00
R / Rfree (%) 16.094 / 18.63

Other elements in 2wzb:

The structure of The Catalytically Active Fully Closed Conformation of Human Phosphoglycerate Kinase in Complex with Adp, 3PG and Magnesium Trifluoride also contains other interesting chemical elements:

Fluorine (F) 3 atoms
Magnesium (Mg) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the The Catalytically Active Fully Closed Conformation of Human Phosphoglycerate Kinase in Complex with Adp, 3PG and Magnesium Trifluoride (pdb code 2wzb). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the The Catalytically Active Fully Closed Conformation of Human Phosphoglycerate Kinase in Complex with Adp, 3PG and Magnesium Trifluoride, PDB code: 2wzb:

Chlorine binding site 1 out of 1 in 2wzb

Go back to Chlorine Binding Sites List in 2wzb
Chlorine binding site 1 out of 1 in the The Catalytically Active Fully Closed Conformation of Human Phosphoglycerate Kinase in Complex with Adp, 3PG and Magnesium Trifluoride


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of The Catalytically Active Fully Closed Conformation of Human Phosphoglycerate Kinase in Complex with Adp, 3PG and Magnesium Trifluoride within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1418

b:17.2
occ:1.00
 O A:HOH2362 3.1 31.9 1.0
N A:ASP218 3.3 5.1 1.0
NH1 A:ARG65 3.4 6.1 1.0
O A:HOH2360 3.5 17.1 1.0
CA A:LYS215 3.5 4.5 1.0
C A:LYS215 3.5 5.4 1.0
CG A:ASP218 3.6 8.3 1.0
CB A:LYS215 3.6 4.5 1.0
CB A:ASP218 3.7 5.3 1.0
N A:ALA217 3.7 5.5 1.0
O A:LYS215 3.8 5.1 1.0
OD2 A:ASP218 3.8 12.2 1.0
CB A:ALA217 3.9 6.7 1.0
OD1 A:ASP218 3.9 9.7 1.0
O A:HOH2147 3.9 22.6 1.0
N A:VAL216 3.9 5.1 1.0
CA A:ALA217 4.1 5.3 1.0
CA A:ASP218 4.1 5.8 1.0
CG A:LYS215 4.2 5.2 1.0
C A:ALA217 4.2 5.9 1.0
NH2 A:ARG65 4.2 2.9 1.0
CZ A:ARG65 4.2 4.1 1.0
C A:VAL216 4.5 5.3 1.0
CA A:VAL216 4.8 5.6 1.0
N A:LYS215 4.9 4.7 1.0
O A:HOH2118 4.9 15.2 1.0
O A:ALA214 5.0 6.8 1.0

Reference:

M.J.Cliff, M.W.Bowler, J.Szabo, J.P.M.Marston, A.V.Varga, A.M.H.Hownslow, N.J.Baxter, G.M.Blackburn, M.Vas, J.P.Waltho. Transition State Analogue Structures of Human Phosphoglycerate Kinase Establish the Importance of Charge Balance in Catalysis. J.Am.Chem.Soc. V. 132 6507 2010.
ISSN: ISSN 0002-7863
PubMed: 20397725
DOI: 10.1021/JA100974T
Page generated: Fri Jul 11 01:43:12 2025

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