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Atomistry » Chlorine » PDB 2xev-2xmc » 2xk8 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 2xev-2xmc » 2xk8 » |
Chlorine in PDB 2xk8: Structure of NEK2 Bound to Aminopyrazine Compound 15Enzymatic activity of Structure of NEK2 Bound to Aminopyrazine Compound 15
All present enzymatic activity of Structure of NEK2 Bound to Aminopyrazine Compound 15:
2.7.11.1; Protein crystallography data
The structure of Structure of NEK2 Bound to Aminopyrazine Compound 15, PDB code: 2xk8
was solved by
C.Mas-Droux,
R.Bayliss,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Structure of NEK2 Bound to Aminopyrazine Compound 15
(pdb code 2xk8). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Structure of NEK2 Bound to Aminopyrazine Compound 15, PDB code: 2xk8: Jump to Chlorine binding site number: 1; 2; 3; 4; Chlorine binding site 1 out of 4 in 2xk8Go back to![]() ![]()
Chlorine binding site 1 out
of 4 in the Structure of NEK2 Bound to Aminopyrazine Compound 15
![]() Mono view ![]() Stereo pair view
Chlorine binding site 2 out of 4 in 2xk8Go back to![]() ![]()
Chlorine binding site 2 out
of 4 in the Structure of NEK2 Bound to Aminopyrazine Compound 15
![]() Mono view ![]() Stereo pair view
Chlorine binding site 3 out of 4 in 2xk8Go back to![]() ![]()
Chlorine binding site 3 out
of 4 in the Structure of NEK2 Bound to Aminopyrazine Compound 15
![]() Mono view ![]() Stereo pair view
Chlorine binding site 4 out of 4 in 2xk8Go back to![]() ![]()
Chlorine binding site 4 out
of 4 in the Structure of NEK2 Bound to Aminopyrazine Compound 15
![]() Mono view ![]() Stereo pair view
Reference:
D.K.Whelligan,
S.Solanki,
D.Taylor,
D.W.Thomson,
K.M.Cheung,
K.Boxall,
C.Mas-Droux,
C.Barillari,
S.Burns,
C.G.Grummitt,
I.Collins,
R.L.Van Montfort,
G.W.Aherne,
R.Bayliss,
S.Hoelder.
Aminopyrazine Inhibitors Binding to An Unusual Inactive Conformation of the Mitotic Kinase NEK2: Sar and Structural Characterization. J.Med.Chem. V. 53 7682 2010.
Page generated: Fri Jul 11 02:00:19 2025
ISSN: ISSN 0022-2623 PubMed: 20936789 DOI: 10.1021/JM1008727 |
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