Chlorine in PDB 2xn5: Crystal Structure of Thyroxine-Binding Globulin Complexed with Furosemide

The structure of Crystal Structure of Thyroxine-Binding Globulin Complexed with Furosemide, PDB code: 2xn5 was solved by X.Qi, Y.Yan, Z.Wei, A.Zhou, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	86.44 / 1.70
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	172.880, 42.150, 56.190, 90.00, 90.00, 90.00
R / Rfree (%)	20.43 / 23.208

The structure of Crystal Structure of Thyroxine-Binding Globulin Complexed with Furosemide also contains other interesting chemical elements:

Calcium

(Ca)

4 atoms

The binding sites of Chlorine atom in the Crystal Structure of Thyroxine-Binding Globulin Complexed with Furosemide (pdb code 2xn5). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Thyroxine-Binding Globulin Complexed with Furosemide, PDB code: 2xn5:

Chlorine binding site 1 out of 1 in the Crystal Structure of Thyroxine-Binding Globulin Complexed with Furosemide


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Thyroxine-Binding Globulin Complexed with Furosemide within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1356 b:30.8 occ:1.00 CL1 A:FUN1356 0.0 30.8 1.0 C2 A:FUN1356 1.8 18.5 1.0 C3 A:FUN1356 2.7 16.2 1.0 C1 A:FUN1356 2.8 17.3 1.0 O2 A:FUN1356 3.0 17.0 1.0 CD1 A:LEU269 3.2 14.7 1.0 S1 A:FUN1356 3.3 14.6 1.0 O B:ARG381 3.3 16.1 1.0 N1 A:FUN1356 3.5 14.9 1.0 CG1 B:ILE383 3.9 14.6 1.0 C4 A:FUN1356 4.0 15.4 1.0 C B:ARG381 4.0 15.6 1.0 CD2 B:LEU376 4.0 21.5 1.0 C11 A:FUN1356 4.1 16.2 1.0 CB A:LEU269 4.2 12.3 1.0 CG A:LEU269 4.3 13.3 1.0 CB B:LEU376 4.5 16.7 1.0 CD1 B:ILE383 4.6 14.3 1.0 C10 A:FUN1356 4.6 15.8 1.0 CD1 B:LEU376 4.6 21.9 1.0 CG B:LEU376 4.6 19.4 1.0 CA B:ARG381 4.7 16.1 1.0 N B:ILE383 4.7 14.1 1.0 O1 A:FUN1356 4.7 17.2 1.0 CB B:ARG381 4.7 16.9 1.0 C B:SER382 4.8 14.5 1.0 N B:SER382 4.8 15.1 1.0

X.Qi, F.Loiseau, W.L.Chan, Y.Yan, Z.Wei, L.G.Milroy, R.M.Myers, S.V.Ley, R.J.Read, R.W.Carrell, A.Zhou. Allosteric Modulation of Hormone Release From Thyroxine and Corticosteroid Binding-Globulins. J.Biol.Chem. V. 286 16163 2011.
ISSN: ISSN 0021-9258
PubMed: 21325280
DOI: 10.1074/JBC.M110.171082