Chlorine in PDB 2y6o: Crystal Structure of EPHA4 Kinase Domain in Complex with Dasatinib.

All present enzymatic activity of Crystal Structure of EPHA4 Kinase Domain in Complex with Dasatinib.:
2.7.10.1;

The structure of Crystal Structure of EPHA4 Kinase Domain in Complex with Dasatinib., PDB code: 2y6o was solved by C.J.A.Farenc, P.H.N.Celie, G.Siegal, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.588 / 1.54
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	32.412, 91.636, 98.346, 90.00, 90.00, 90.00
R / Rfree (%)	18.01 / 20.05

The binding sites of Chlorine atom in the Crystal Structure of EPHA4 Kinase Domain in Complex with Dasatinib. (pdb code 2y6o). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of EPHA4 Kinase Domain in Complex with Dasatinib., PDB code: 2y6o:

Chlorine binding site 1 out of 1 in the Crystal Structure of EPHA4 Kinase Domain in Complex with Dasatinib.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of EPHA4 Kinase Domain in Complex with Dasatinib. within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1892 b:25.4 occ:1.00 CL A:1N11892 0.0 25.4 1.0 C5 A:1N11892 1.7 15.8 1.0 C4 A:1N11892 2.7 11.9 1.0 C6 A:1N11892 2.7 15.6 1.0 OG A:SER763 2.7 19.2 0.6 N2 A:1N11892 3.0 11.3 1.0 C3 A:1N11892 3.3 13.3 1.0 O A:1N11892 3.4 15.4 1.0 CB A:SER763 3.6 21.5 0.4 CB A:SER763 3.8 20.6 0.6 C7 A:1N11892 4.0 18.1 1.0 C9 A:1N11892 4.0 11.7 1.0 CD1 A:LEU753 4.0 11.9 1.0 CG1 A:ILE683 4.1 16.3 0.7 CG2 A:ILE683 4.2 12.9 0.7 CG1 A:ILE683 4.2 12.7 0.3 CG2 A:ILE683 4.2 14.4 0.3 O A:HOH2167 4.2 30.7 1.0 O A:HOH2298 4.2 37.5 1.0 OG A:SER763 4.3 16.9 0.4 C2 A:1N11892 4.4 9.8 1.0 C8 A:1N11892 4.5 16.3 1.0 CB A:ILE683 4.5 8.8 0.7 CB A:ILE683 4.5 9.2 0.3 N A:ASP764 4.5 26.0 1.0 CA A:SER763 4.6 14.2 0.6 CA A:SER763 4.6 14.5 0.4 CD1 A:ILE683 4.8 15.4 0.7 SD A:MET674 4.8 23.7 0.5 O A:HOH2299 4.9 34.6 1.0 C1 A:1N11892 4.9 11.6 1.0 CG2 A:THR699 4.9 8.9 1.0 CD1 A:ILE683 5.0 8.9 0.3

C.J.A.Farenc, L.Hameetman, W.Zoutman, C.P.Tensen, G.Siegal. Crystal Structure of the EPHA4 Protein Tyrosine Kinase Domain in the Apo- and Dasatinib-Bound State. Febs Lett. V. 585 3593 2011.
ISSN: ISSN 0014-5793
PubMed: 22036717
DOI: 10.1016/J.FEBSLET.2011.10.028