Chlorine in PDB 3amv: Allosteric Inhibition of Glycogen Phosphorylase A By A Potential Antidiabetic Drug

All present enzymatic activity of Allosteric Inhibition of Glycogen Phosphorylase A By A Potential Antidiabetic Drug:
2.4.1.1;

The structure of Allosteric Inhibition of Glycogen Phosphorylase A By A Potential Antidiabetic Drug, PDB code: 3amv was solved by N.G.Oikonomakos, K.E.Tsitsanou, S.E.Zographos, V.T.Skamnaki, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	13.00 / 2.10
Space group	P 43 21 2
Cell size a, b, c (Å), α, β, γ (°)	127.200, 127.200, 115.800, 90.00, 90.00, 90.00
R / Rfree (%)	18.9 / 26

The binding sites of Chlorine atom in the Allosteric Inhibition of Glycogen Phosphorylase A By A Potential Antidiabetic Drug (pdb code 3amv). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Allosteric Inhibition of Glycogen Phosphorylase A By A Potential Antidiabetic Drug, PDB code: 3amv:

Chlorine binding site 1 out of 1 in the Allosteric Inhibition of Glycogen Phosphorylase A By A Potential Antidiabetic Drug


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Allosteric Inhibition of Glycogen Phosphorylase A By A Potential Antidiabetic Drug within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl930 b:4.1 occ:1.00 CL2 A:BIN930 0.0 4.1 1.0 C2 A:BIN930 1.6 21.5 1.0 C3 A:BIN930 2.7 26.6 1.0 C1 A:BIN930 2.8 26.2 1.0 NH1 A:ARG193 2.8 45.0 1.0 C7 A:BIN930 3.3 27.1 1.0 O A:HOH1409 3.4 26.3 1.0 O3B A:BIN930 3.4 31.1 1.0 O8 A:BIN930 3.5 25.7 1.0 CD A:ARG193 3.7 36.0 1.0 CZ A:ARG193 3.7 39.5 1.0 OD2 A:ASP227 3.8 19.2 1.0 NH2 A:ARG242 3.9 28.7 1.0 C20 A:BIN930 4.0 26.3 1.0 NE A:ARG193 4.0 35.8 1.0 C4 A:BIN930 4.0 25.2 1.0 C6 A:BIN930 4.1 27.5 1.0 C19 A:BIN930 4.2 25.1 1.0 C13 A:BIN930 4.2 25.7 1.0 C21 A:BIN930 4.2 20.6 1.0 C12 A:BIN930 4.3 25.9 1.0 O A:HOH1357 4.4 32.6 1.0 C18 A:BIN930 4.4 25.4 1.0 C8 A:BIN930 4.4 25.2 1.0 C5 A:BIN930 4.6 24.2 1.0 NH2 A:ARG193 4.7 41.0 1.0 CE2 A:PHE196 4.8 25.3 1.0

N.G.Oikonomakos, K.E.Tsitsanou, S.E.Zographos, V.T.Skamnaki, S.Goldmann, H.Bischoff. Allosteric Inhibition of Glycogen Phosphorylase A By the Potential Antidiabetic Drug 3-Isopropyl 4-(2-Chlorophenyl)-1,4-Dihydro-1-Ethyl-2-Methyl-Pyridine-3, 5,6-Tricarbo Xylate. Protein Sci. V. 8 1930 1999.
ISSN: ISSN 0961-8368
PubMed: 10548038