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Chlorine in PDB 3bi0: X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Transition State Analog of Glu-Glu

Enzymatic activity of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Transition State Analog of Glu-Glu

All present enzymatic activity of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Transition State Analog of Glu-Glu:
3.4.17.21;

Protein crystallography data

The structure of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Transition State Analog of Glu-Glu, PDB code: 3bi0 was solved by J.Lubkowski, C.Barinka, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 15.00 / 1.67
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 102.405, 130.797, 159.140, 90.00, 90.00, 90.00
R / Rfree (%) 18.3 / 21.1

Other elements in 3bi0:

The structure of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Transition State Analog of Glu-Glu also contains other interesting chemical elements:

Calcium (Ca) 1 atom
Zinc (Zn) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Transition State Analog of Glu-Glu (pdb code 3bi0). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Transition State Analog of Glu-Glu, PDB code: 3bi0:

Chlorine binding site 1 out of 1 in 3bi0

Go back to Chlorine Binding Sites List in 3bi0
Chlorine binding site 1 out of 1 in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Transition State Analog of Glu-Glu


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Transition State Analog of Glu-Glu within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1754

b:25.2
occ:1.00
 O A:HOH1788 3.1 23.7 1.0
NH1 A:ARG536 3.3 17.9 0.3
ND2 A:ASN451 3.3 21.5 1.0
NE A:ARG534 3.3 27.0 1.0
N A:ASP453 3.4 19.7 1.0
NH1 A:ARG534 3.4 28.4 1.0
CB A:ASP453 3.8 19.8 1.0
CZ A:ARG534 3.8 29.5 1.0
NH2 A:ARG580 3.8 20.1 1.0
CB A:ARG534 3.9 19.1 1.0
CA A:ASP453 4.0 18.7 1.0
CB A:ASN451 4.0 19.0 1.0
CG A:ASN451 4.1 18.4 1.0
N A:ALA452 4.2 18.7 1.0
CZ A:ARG536 4.2 22.6 0.3
C A:ASP453 4.3 20.4 1.0
C A:ASN451 4.3 18.9 1.0
O A:ASP453 4.4 20.2 1.0
C A:ALA452 4.4 19.5 1.0
CD A:ARG536 4.4 25.9 0.7
CA A:ALA452 4.4 19.9 1.0
CD A:ARG534 4.4 26.4 1.0
O A:ASN451 4.5 20.0 1.0
CG A:ARG534 4.6 19.7 1.0
CZ A:ARG580 4.7 22.2 1.0
O A:HOH2397 4.7 43.5 1.0
NE A:ARG536 4.8 28.8 0.7
O A:ALA535 4.8 19.5 1.0
O A:SER454 4.8 22.1 1.0
NE A:ARG536 4.8 25.4 0.3
CA A:ASN451 4.9 17.5 1.0
CA A:ARG534 4.9 19.6 1.0
N A:SER454 4.9 19.9 1.0
N A:ALA535 4.9 19.2 1.0
ND2 A:ASN519 5.0 19.9 1.0

Reference:

C.Barinka, K.Hlouchova, M.Rovenska, P.Majer, M.Dauter, N.Hin, Y.S.Ko, T.Tsukamoto, B.S.Slusher, J.Konvalinka, J.Lubkowski. Structural Basis of Interactions Between Human Glutamate Carboxypeptidase II and Its Substrate Analogs J.Mol.Biol. V. 376 1438 2008.
ISSN: ISSN 0022-2836
PubMed: 18234225
DOI: 10.1016/J.JMB.2007.12.066
Page generated: Fri Jul 11 03:27:34 2025

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