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Atomistry » Chlorine » PDB 3ccq-3ck1 » 3cen » |
Chlorine in PDB 3cen: Factor Xa in Complex with the Inhibitor N-(2-(((5-Chloro-2- Pyridinyl) Amino)Sulfonyl)Phenyl)-4-(2-Oxo-1(2H)- Pyridinyl)BenzamideEnzymatic activity of Factor Xa in Complex with the Inhibitor N-(2-(((5-Chloro-2- Pyridinyl) Amino)Sulfonyl)Phenyl)-4-(2-Oxo-1(2H)- Pyridinyl)Benzamide
All present enzymatic activity of Factor Xa in Complex with the Inhibitor N-(2-(((5-Chloro-2- Pyridinyl) Amino)Sulfonyl)Phenyl)-4-(2-Oxo-1(2H)- Pyridinyl)Benzamide:
3.4.21.6; Protein crystallography data
The structure of Factor Xa in Complex with the Inhibitor N-(2-(((5-Chloro-2- Pyridinyl) Amino)Sulfonyl)Phenyl)-4-(2-Oxo-1(2H)- Pyridinyl)Benzamide, PDB code: 3cen
was solved by
C.-H.Chang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Factor Xa in Complex with the Inhibitor N-(2-(((5-Chloro-2- Pyridinyl) Amino)Sulfonyl)Phenyl)-4-(2-Oxo-1(2H)- Pyridinyl)Benzamide
(pdb code 3cen). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Factor Xa in Complex with the Inhibitor N-(2-(((5-Chloro-2- Pyridinyl) Amino)Sulfonyl)Phenyl)-4-(2-Oxo-1(2H)- Pyridinyl)Benzamide, PDB code: 3cen: Chlorine binding site 1 out of 1 in 3cenGo back to![]() ![]()
Chlorine binding site 1 out
of 1 in the Factor Xa in Complex with the Inhibitor N-(2-(((5-Chloro-2- Pyridinyl) Amino)Sulfonyl)Phenyl)-4-(2-Oxo-1(2H)- Pyridinyl)Benzamide
![]() Mono view ![]() Stereo pair view
Reference:
J.R.Corte,
T.Fang,
D.J.P.Pinto,
W.Han,
Z.Hu,
X.-J.Jiang,
Y.-L.Li,
J.F.Gauuan,
M.Hadden,
D.Orton,
A.R.Rendina,
J.M.Luettgen,
P.C.Wong,
K.He,
P.Morin,
C.-H.Chang,
D.L.Cheney,
R.M.Knabb,
R.R.Wexler,
P.Y.S.Lam.
Structure-Activity Relationships of Anthranilamide-Based Factor Xa Inhibitors Containing Piperidinone and Pyridinone P4 Moieties Bioorg.Med.Chem.Lett. V. 18 2845 2008.
Page generated: Sat Jul 20 17:27:47 2024
ISSN: ISSN 0960-894X PubMed: 18424044 DOI: 10.1016/J.BMCL.2008.03.092 |
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