|
Atomistry » Chlorine » PDB 3ct9-3d44 » 3d2k | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 3ct9-3d44 » 3d2k » |
Chlorine in PDB 3d2k: Crystal Structure of Mouse Aurora A (ASN186->Gly, LYS240- >Arg, MET302->Leu) in Complex with [7-(2-{2-[3-(3-Chloro- Phenyl)-Ureido]-Thiazol-5-Yl}-Ethylamino)-Pyrazolo[4,3- D]Pyrimidin-1-Yl]-Acetic AcidEnzymatic activity of Crystal Structure of Mouse Aurora A (ASN186->Gly, LYS240- >Arg, MET302->Leu) in Complex with [7-(2-{2-[3-(3-Chloro- Phenyl)-Ureido]-Thiazol-5-Yl}-Ethylamino)-Pyrazolo[4,3- D]Pyrimidin-1-Yl]-Acetic Acid
All present enzymatic activity of Crystal Structure of Mouse Aurora A (ASN186->Gly, LYS240- >Arg, MET302->Leu) in Complex with [7-(2-{2-[3-(3-Chloro- Phenyl)-Ureido]-Thiazol-5-Yl}-Ethylamino)-Pyrazolo[4,3- D]Pyrimidin-1-Yl]-Acetic Acid:
2.7.11.1; Protein crystallography data
The structure of Crystal Structure of Mouse Aurora A (ASN186->Gly, LYS240- >Arg, MET302->Leu) in Complex with [7-(2-{2-[3-(3-Chloro- Phenyl)-Ureido]-Thiazol-5-Yl}-Ethylamino)-Pyrazolo[4,3- D]Pyrimidin-1-Yl]-Acetic Acid, PDB code: 3d2k
was solved by
R.A.Elling,
J.D.Oslob,
C.Yu,
M.J.Romanowski,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Mouse Aurora A (ASN186->Gly, LYS240- >Arg, MET302->Leu) in Complex with [7-(2-{2-[3-(3-Chloro- Phenyl)-Ureido]-Thiazol-5-Yl}-Ethylamino)-Pyrazolo[4,3- D]Pyrimidin-1-Yl]-Acetic Acid
(pdb code 3d2k). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Mouse Aurora A (ASN186->Gly, LYS240- >Arg, MET302->Leu) in Complex with [7-(2-{2-[3-(3-Chloro- Phenyl)-Ureido]-Thiazol-5-Yl}-Ethylamino)-Pyrazolo[4,3- D]Pyrimidin-1-Yl]-Acetic Acid, PDB code: 3d2k: Chlorine binding site 1 out of 1 in 3d2kGo back to![]() ![]()
Chlorine binding site 1 out
of 1 in the Crystal Structure of Mouse Aurora A (ASN186->Gly, LYS240- >Arg, MET302->Leu) in Complex with [7-(2-{2-[3-(3-Chloro- Phenyl)-Ureido]-Thiazol-5-Yl}-Ethylamino)-Pyrazolo[4,3- D]Pyrimidin-1-Yl]-Acetic Acid
![]() Mono view ![]() Stereo pair view
Reference:
J.D.Oslob,
C.Yu,
D.A.Allen,
S.Baskaran,
J.Maung,
E.F.Michelotti,
R.A.Elling,
M.J.Romanowski.
Discovery of Aurora-A-Selective Inhibitors To Be Published.
Page generated: Sat Jul 20 17:59:55 2024
|
Last articlesZn in 9MJ5Zn in 9HNW Zn in 9G0L Zn in 9FNE Zn in 9DZN Zn in 9E0I Zn in 9D32 Zn in 9DAK Zn in 8ZXC Zn in 8ZUF |
© Copyright 2008-2020 by atomistry.com | ||
Home | Site Map | Copyright | Contact us | Privacy |