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Atomistry » Chlorine » PDB 3dna-3dzc » 3drr | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 3dna-3dzc » 3drr » |
Chlorine in PDB 3drr: Hiv Reverse Transcriptase Y181C Mutant in Complex with Inhibitor R8EEnzymatic activity of Hiv Reverse Transcriptase Y181C Mutant in Complex with Inhibitor R8E
All present enzymatic activity of Hiv Reverse Transcriptase Y181C Mutant in Complex with Inhibitor R8E:
2.7.7.49; 2.7.7.7; 3.1.26.4; Protein crystallography data
The structure of Hiv Reverse Transcriptase Y181C Mutant in Complex with Inhibitor R8E, PDB code: 3drr
was solved by
Y.Yan,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Hiv Reverse Transcriptase Y181C Mutant in Complex with Inhibitor R8E
(pdb code 3drr). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Hiv Reverse Transcriptase Y181C Mutant in Complex with Inhibitor R8E, PDB code: 3drr: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 3drrGo back to![]() ![]()
Chlorine binding site 1 out
of 2 in the Hiv Reverse Transcriptase Y181C Mutant in Complex with Inhibitor R8E
![]() Mono view ![]() Stereo pair view
Chlorine binding site 2 out of 2 in 3drrGo back to![]() ![]()
Chlorine binding site 2 out
of 2 in the Hiv Reverse Transcriptase Y181C Mutant in Complex with Inhibitor R8E
![]() Mono view ![]() Stereo pair view
Reference:
T.J.Tucker,
J.T.Sisko,
R.M.Tynebor,
T.M.Williams,
P.J.Felock,
J.A.Flynn,
M.T.Lai,
Y.Liang,
G.Mcgaughey,
M.Liu,
M.Miller,
G.Moyer,
V.Munshi,
R.Perlow-Poehnelt,
S.Prasad,
J.C.Reid,
R.Sanchez,
M.Torrent,
J.P.Vacca,
B.L.Wan,
Y.Yan.
Discovery of 3-{5-[(6-Amino-1H-Pyrazolo[3,4-B]Pyridine-3-Yl) Methoxy]-2-Chlorophenoxy}-5-Chlorobenzonitrile (Mk-4965): A Potent, Orally Bioavailable Hiv-1 Non-Nucleoside Reverse Transcriptase Inhibitor with Improved Potency Against Key Mutant Viruses. J.Med.Chem. V. 51 6503 2008.
Page generated: Fri Jul 11 04:37:52 2025
ISSN: ISSN 0022-2623 PubMed: 18826204 DOI: 10.1021/JM800856C |
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