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Atomistry » Chlorine » PDB 3gky-3gxg » 3gnv | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 3gky-3gxg » 3gnv » |
Chlorine in PDB 3gnv: Hcv NS5B Polymerase in Complex with 1,5 Benzodiazepine Inhibitor 1BEnzymatic activity of Hcv NS5B Polymerase in Complex with 1,5 Benzodiazepine Inhibitor 1B
All present enzymatic activity of Hcv NS5B Polymerase in Complex with 1,5 Benzodiazepine Inhibitor 1B:
2.7.7.48; Protein crystallography data
The structure of Hcv NS5B Polymerase in Complex with 1,5 Benzodiazepine Inhibitor 1B, PDB code: 3gnv
was solved by
H.De Bondt,
O.Nyanguile,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Hcv NS5B Polymerase in Complex with 1,5 Benzodiazepine Inhibitor 1B
(pdb code 3gnv). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Hcv NS5B Polymerase in Complex with 1,5 Benzodiazepine Inhibitor 1B, PDB code: 3gnv: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 3gnvGo back to![]() ![]()
Chlorine binding site 1 out
of 2 in the Hcv NS5B Polymerase in Complex with 1,5 Benzodiazepine Inhibitor 1B
![]() Mono view ![]() Stereo pair view
Chlorine binding site 2 out of 2 in 3gnvGo back to![]() ![]()
Chlorine binding site 2 out
of 2 in the Hcv NS5B Polymerase in Complex with 1,5 Benzodiazepine Inhibitor 1B
![]() Mono view ![]() Stereo pair view
Reference:
K.Vandyck,
M.D.Cummings,
O.Nyanguile,
C.W.Boutton,
S.Vendeville,
D.Mcgowan,
B.Devogelaere,
K.Amssoms,
S.Last,
K.Rombauts,
A.Tahri,
P.Lory,
L.Hu,
D.A.Beauchamp,
K.Simmen,
P.Raboisson.
Structure-Based Design of A Benzodiazepine Scaffold Yields A Potent Allosteric Inhibitor of Hepatitis C NS5B Rna Polymerase. J.Med.Chem. V. 52 4099 2009.
Page generated: Fri Jul 11 05:42:58 2025
ISSN: ISSN 0022-2623 PubMed: 19507864 DOI: 10.1021/JM9005548 |
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