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Atomistry » Chlorine » PDB 3hd1-3hl7 » 3heg » |
Chlorine in PDB 3heg: P38 in Complex with SorafenibEnzymatic activity of P38 in Complex with Sorafenib
All present enzymatic activity of P38 in Complex with Sorafenib:
2.7.11.24; Protein crystallography data
The structure of P38 in Complex with Sorafenib, PDB code: 3heg
was solved by
H.V.Namboodiri,
M.Karpusas,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3heg:
The structure of P38 in Complex with Sorafenib also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the P38 in Complex with Sorafenib
(pdb code 3heg). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the P38 in Complex with Sorafenib, PDB code: 3heg: Chlorine binding site 1 out of 1 in 3hegGo back to![]() ![]()
Chlorine binding site 1 out
of 1 in the P38 in Complex with Sorafenib
![]() Mono view ![]() Stereo pair view
Reference:
H.V.Namboodiri,
M.Bukhtiyarova,
J.Ramcharan,
M.Karpusas,
Y.Lee,
E.B.Springman.
Analysis of Imatinib and Sorafenib Binding to P38ALPHA Compared with C-Abl and B-Raf Provides Structural Insights For Understanding the Selectivity of Inhibitors Targeting the Dfg-Out Form of Protein Kinases. Biochemistry V. 49 3611 2010.
Page generated: Sat Jul 20 20:47:09 2024
ISSN: ISSN 0006-2960 PubMed: 20337484 DOI: 10.1021/BI100070R |
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