Atomistry » Chlorine » PDB 3hl8-3hwl » 3hng
Atomistry »
  Chlorine »
    PDB 3hl8-3hwl »
      3hng »

Chlorine in PDB 3hng: Crystal Structure of VEGFR1 in Complex with N-(4-Chlorophenyl)-2- ((Pyridin-4-Ylmethyl)Amino)Benzamide

Enzymatic activity of Crystal Structure of VEGFR1 in Complex with N-(4-Chlorophenyl)-2- ((Pyridin-4-Ylmethyl)Amino)Benzamide

All present enzymatic activity of Crystal Structure of VEGFR1 in Complex with N-(4-Chlorophenyl)-2- ((Pyridin-4-Ylmethyl)Amino)Benzamide:
2.7.10.1;

Protein crystallography data

The structure of Crystal Structure of VEGFR1 in Complex with N-(4-Chlorophenyl)-2- ((Pyridin-4-Ylmethyl)Amino)Benzamide, PDB code: 3hng was solved by L.Tresaugues, A.Roos, C.H.Arrowsmith, H.Berglund, C.Bountra, R.Collins, A.M.Edwards, S.Flodin, A.Flores, S.Graslund, M.Hammarstrom, A.Johansson, I.Johansson, T.Karlberg, T.Kotenyova, M.Moche, T.Nyman, C.Persson, T.Kragh-Nielsen, A.Kotzch, J.Sagemark, H.Schueler, P.Schutz, M.I.Siponen, L.Svensson, A.G.Thorsell, S.Van Der Berg, J.Weigelt, M.Welin, M.Wisniewska, P.Nordlund, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 44.99 / 2.70
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 58.040, 71.150, 196.020, 90.00, 90.00, 90.00
R / Rfree (%) 19.4 / 26

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of VEGFR1 in Complex with N-(4-Chlorophenyl)-2- ((Pyridin-4-Ylmethyl)Amino)Benzamide (pdb code 3hng). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of VEGFR1 in Complex with N-(4-Chlorophenyl)-2- ((Pyridin-4-Ylmethyl)Amino)Benzamide, PDB code: 3hng:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 3hng

Go back to Chlorine Binding Sites List in 3hng
Chlorine binding site 1 out of 2 in the Crystal Structure of VEGFR1 in Complex with N-(4-Chlorophenyl)-2- ((Pyridin-4-Ylmethyl)Amino)Benzamide


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of VEGFR1 in Complex with N-(4-Chlorophenyl)-2- ((Pyridin-4-Ylmethyl)Amino)Benzamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl2001

b:46.1
occ:1.00
CL16 A:8ST2001 0.0 46.1 1.0
C13 A:8ST2001 1.8 40.6 1.0
C12 A:8ST2001 2.7 37.7 1.0
C14 A:8ST2001 2.8 38.1 1.0
CD1 A:LEU1013 3.5 24.9 1.0
CD2 A:HIS1020 3.9 26.5 1.0
C15 A:8ST2001 4.0 36.0 1.0
C11 A:8ST2001 4.0 36.8 1.0
CD2 A:LEU1013 4.3 24.1 1.0
NE2 A:HIS1020 4.4 27.4 1.0
C10 A:8ST2001 4.5 34.4 1.0
CG A:LEU1013 4.6 24.4 1.0
CG2 A:ILE1038 4.6 24.4 1.0
SG A:CYS1018 4.7 33.0 1.0
CG1 A:VAL891 4.8 22.7 1.0
CD1 A:ILE885 4.9 37.9 1.0
CG A:HIS1020 5.0 26.6 1.0

Chlorine binding site 2 out of 2 in 3hng

Go back to Chlorine Binding Sites List in 3hng
Chlorine binding site 2 out of 2 in the Crystal Structure of VEGFR1 in Complex with N-(4-Chlorophenyl)-2- ((Pyridin-4-Ylmethyl)Amino)Benzamide


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of VEGFR1 in Complex with N-(4-Chlorophenyl)-2- ((Pyridin-4-Ylmethyl)Amino)Benzamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl3035

b:67.8
occ:1.00
N A:LYS850 3.5 28.0 1.0
O A:LEU895 3.8 24.3 1.0
CD1 A:PHE822 4.0 24.2 1.0
CA A:LYS850 4.1 29.2 1.0
O A:GLU821 4.1 22.9 1.0
O A:TRP820 4.2 22.6 1.0
O A:LYS819 4.3 23.4 1.0
NZ A:LYS851 4.4 38.7 1.0
CB A:PHE822 4.5 24.5 1.0
C A:ILE849 4.6 26.8 1.0
C A:TRP820 4.6 23.1 1.0
CA A:GLY896 4.7 24.3 1.0
CG A:PHE822 4.7 24.3 1.0
CA A:ILE849 4.7 26.1 1.0
CE1 A:PHE822 4.8 24.6 1.0
N A:LYS851 4.8 29.6 1.0
CA A:TRP820 4.8 23.9 1.0
C A:LEU895 4.9 24.0 1.0
C A:GLU821 4.9 23.1 1.0
C A:LYS850 4.9 29.3 1.0
CE A:LYS851 4.9 36.5 1.0
CD1 A:ILE849 5.0 29.0 1.0

Reference:

L.Tresaugues, A.Roos, C.H.Arrowsmith, H.Berglund, C.Bountra, R.Collins, A.M.Edwards, S.Flodin, A.Flores, S.Graslund, M.Hammarstrom, A.Johansson, I.Johansson, T.Karlberg, T.Kotenyova, M.Moche, T.Nyman, C.Persson, T.Kragh-Nielsen, A.Kotzch, J.Sagemark, H.Schueler, P.Schutz, M.I.Siponen, L.Svensson, A.G.Thorsell, S.Van Der Berg, J.Weigelt, M.Welin, M.Wisniewska, P.Nordlund. Crystal Structure of VEGFR1 in Complex with N-(4-Chlorophenyl)-2-((Pyridin-4-Ylmethyl)Amino)Benzamide To Be Published.
Page generated: Fri Jul 11 06:03:17 2025

Last articles

Fe in 2YXO
Fe in 2YRS
Fe in 2YXC
Fe in 2YNM
Fe in 2YVJ
Fe in 2YP1
Fe in 2YU2
Fe in 2YU1
Fe in 2YQB
Fe in 2YOO
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy