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Chlorine in PDB 3jps: Ternary Complex of Dna Polymerase Beta with A Dideoxy Terminated Primer and 2'-Deoxyguanosine 5'-Beta, Gamma-Fluoro Methyl Methylene Triphosphate
Enzymatic activity of Ternary Complex of Dna Polymerase Beta with A Dideoxy Terminated Primer and 2'-Deoxyguanosine 5'-Beta, Gamma-Fluoro Methyl Methylene Triphosphate
All present enzymatic activity of Ternary Complex of Dna Polymerase Beta with A Dideoxy Terminated Primer and 2'-Deoxyguanosine 5'-Beta, Gamma-Fluoro Methyl Methylene Triphosphate:
2.7.7.7;
2.7.7.7;
Protein crystallography data
The structure of Ternary Complex of Dna Polymerase Beta with A Dideoxy Terminated Primer and 2'-Deoxyguanosine 5'-Beta, Gamma-Fluoro Methyl Methylene Triphosphate, PDB code: 3jps
was solved by
V.K.Batra,
J.Upton,
B.Kashmerov,
W.A.Beard,
S.H.Wilson,
M.F.Goodman,
C.E.Mckenna,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 24.98 / 2.00 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 50.570, 79.860, 55.550, 90.00, 107.84, 90.00 |
| R / Rfree (%) | 19.1 / 23.7 |
Other elements in 3jps:
The structure of Ternary Complex of Dna Polymerase Beta with A Dideoxy Terminated Primer and 2'-Deoxyguanosine 5'-Beta, Gamma-Fluoro Methyl Methylene Triphosphate also contains other interesting chemical elements:
| Fluorine | (F) | 1 atom |
| Magnesium | (Mg) | 1 atom |
| Sodium | (Na) | 3 atoms |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Ternary Complex of Dna Polymerase Beta with A Dideoxy Terminated Primer and 2'-Deoxyguanosine 5'-Beta, Gamma-Fluoro Methyl Methylene Triphosphate
(pdb code 3jps). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Ternary Complex of Dna Polymerase Beta with A Dideoxy Terminated Primer and 2'-Deoxyguanosine 5'-Beta, Gamma-Fluoro Methyl Methylene Triphosphate, PDB code: 3jps:
Jump to Chlorine binding site number: 1; 2; 3;
In total 3 binding sites of Chlorine where determined in the Ternary Complex of Dna Polymerase Beta with A Dideoxy Terminated Primer and 2'-Deoxyguanosine 5'-Beta, Gamma-Fluoro Methyl Methylene Triphosphate, PDB code: 3jps:
Jump to Chlorine binding site number: 1; 2; 3;
Chlorine binding site 1 out of 3 in 3jps
Go back to
Chlorine Binding Sites List in 3jps
Chlorine binding site 1 out
of 3 in the Ternary Complex of Dna Polymerase Beta with A Dideoxy Terminated Primer and 2'-Deoxyguanosine 5'-Beta, Gamma-Fluoro Methyl Methylene Triphosphate
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Ternary Complex of Dna Polymerase Beta with A Dideoxy Terminated Primer and 2'-Deoxyguanosine 5'-Beta, Gamma-Fluoro Methyl Methylene Triphosphate within 5.0Å range:
|
Chlorine binding site 2 out of 3 in 3jps
Go back to
Chlorine Binding Sites List in 3jps
Chlorine binding site 2 out
of 3 in the Ternary Complex of Dna Polymerase Beta with A Dideoxy Terminated Primer and 2'-Deoxyguanosine 5'-Beta, Gamma-Fluoro Methyl Methylene Triphosphate
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Ternary Complex of Dna Polymerase Beta with A Dideoxy Terminated Primer and 2'-Deoxyguanosine 5'-Beta, Gamma-Fluoro Methyl Methylene Triphosphate within 5.0Å range:
|
Chlorine binding site 3 out of 3 in 3jps
Go back to
Chlorine Binding Sites List in 3jps
Chlorine binding site 3 out
of 3 in the Ternary Complex of Dna Polymerase Beta with A Dideoxy Terminated Primer and 2'-Deoxyguanosine 5'-Beta, Gamma-Fluoro Methyl Methylene Triphosphate
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of Ternary Complex of Dna Polymerase Beta with A Dideoxy Terminated Primer and 2'-Deoxyguanosine 5'-Beta, Gamma-Fluoro Methyl Methylene Triphosphate within 5.0Å range:
|
Reference:
V.K.Batra,
L.C.Pedersen,
W.A.Beard,
S.H.Wilson,
B.A.Kashemirov,
T.G.Upton,
M.F.Goodman,
C.E.Mckenna.
Halogenated Beta,Gamma-Methylene- and Ethylidene-Dgtp-Dna Ternary Complexes with Dna Polymerase Beta: Structural Evidence For Stereospecific Binding of the Fluoromethylene Analogues. J.Am.Chem.Soc. V. 132 7617 2010.
ISSN: ISSN 0002-7863
PubMed: 20465217
DOI: 10.1021/JA909370K
Page generated: Fri Jul 11 06:41:02 2025
ISSN: ISSN 0002-7863
PubMed: 20465217
DOI: 10.1021/JA909370K
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