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Chlorine in PDB 3k2l: Crystal Structure of Dual-Specificity Tyrosine Phosphorylation Regulated Kinase 2 (DYRK2)

Enzymatic activity of Crystal Structure of Dual-Specificity Tyrosine Phosphorylation Regulated Kinase 2 (DYRK2)

All present enzymatic activity of Crystal Structure of Dual-Specificity Tyrosine Phosphorylation Regulated Kinase 2 (DYRK2):
2.7.12.1;

Protein crystallography data

The structure of Crystal Structure of Dual-Specificity Tyrosine Phosphorylation Regulated Kinase 2 (DYRK2), PDB code: 3k2l was solved by P.Filippakopoulos, V.Myrianthopoulos, M.Soundararajan, T.Krojer, E.Hapka, O.Fedorov, G.Berridge, J.Wang, L.Shrestha, A.C.W.Pike, E.Ugochukwu, F.Vondelft, C.H.Arrowsmith, A.Edwards, J.Weigelt, C.Bountra, E.Mikros, S.Knapp, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 40.54 / 2.36
Space group P 42 21 2
Cell size a, b, c (Å), α, β, γ (°) 84.285, 84.285, 148.505, 90.00, 90.00, 90.00
R / Rfree (%) 22.5 / 28.8

Other elements in 3k2l:

The structure of Crystal Structure of Dual-Specificity Tyrosine Phosphorylation Regulated Kinase 2 (DYRK2) also contains other interesting chemical elements:

Sodium (Na) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Dual-Specificity Tyrosine Phosphorylation Regulated Kinase 2 (DYRK2) (pdb code 3k2l). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Dual-Specificity Tyrosine Phosphorylation Regulated Kinase 2 (DYRK2), PDB code: 3k2l:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 3k2l

Go back to Chlorine Binding Sites List in 3k2l
Chlorine binding site 1 out of 2 in the Crystal Structure of Dual-Specificity Tyrosine Phosphorylation Regulated Kinase 2 (DYRK2)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Dual-Specificity Tyrosine Phosphorylation Regulated Kinase 2 (DYRK2) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl481

b:61.3
occ:1.00
N A:HIS174 3.5 35.5 1.0
CB A:GLN173 3.8 39.2 1.0
CA A:GLN173 3.9 38.1 1.0
ND1 A:HIS174 4.0 31.0 1.0
C A:GLN173 4.2 34.0 1.0
CB A:HIS174 4.3 30.8 1.0
CA A:HIS174 4.5 33.4 1.0
CG A:HIS174 4.6 31.6 1.0
O A:HIS174 4.9 41.4 1.0

Chlorine binding site 2 out of 2 in 3k2l

Go back to Chlorine Binding Sites List in 3k2l
Chlorine binding site 2 out of 2 in the Crystal Structure of Dual-Specificity Tyrosine Phosphorylation Regulated Kinase 2 (DYRK2)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Dual-Specificity Tyrosine Phosphorylation Regulated Kinase 2 (DYRK2) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl482

b:79.2
occ:1.00
NZ A:LYS413 3.1 63.9 1.0
NH1 A:ARG411 3.8 69.2 1.0
CE A:LYS413 4.2 63.7 1.0
CD A:LYS413 4.2 53.6 1.0
CZ A:ARG411 5.0 62.1 1.0

Reference:

M.Soundararajan, A.K.Roos, P.Savitsky, P.Filippakopoulos, A.N.Kettenbach, J.V.Olsen, S.A.Gerber, J.Eswaran, S.Knapp, J.M.Elkins. Structures of Down Syndrome Kinases, Dyrks, Reveal Mechanisms of Kinase Activation and Substrate Recognition. Structure V. 21 986 2013.
ISSN: ISSN 0969-2126
PubMed: 23665168
DOI: 10.1016/J.STR.2013.03.012
Page generated: Fri Jul 11 06:49:59 2025

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