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Chlorine in PDB 3k54: Structures of Human Bruton'S Tyrosine Kinase in Active and Inactive Conformations Suggests A Mechanism of Activation For Tec Family Kinases.

Enzymatic activity of Structures of Human Bruton'S Tyrosine Kinase in Active and Inactive Conformations Suggests A Mechanism of Activation For Tec Family Kinases.

All present enzymatic activity of Structures of Human Bruton'S Tyrosine Kinase in Active and Inactive Conformations Suggests A Mechanism of Activation For Tec Family Kinases.:
2.7.10.2;

Protein crystallography data

The structure of Structures of Human Bruton'S Tyrosine Kinase in Active and Inactive Conformations Suggests A Mechanism of Activation For Tec Family Kinases., PDB code: 3k54 was solved by D.J.Marcotte, Y.-T.Liu, R.M.Arduini, C.A.Hession, K.Miatkowski, C.P.Wildes, P.F.Cullen, B.T.Hopkins, E.Mertsching, T.J.Jenkins, M.J.Romanowski, D.P.Baker, L.F.Silvian, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 28.40 / 1.94
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 73.438, 104.622, 38.107, 90.00, 90.00, 90.00
R / Rfree (%) 19.9 / 25.8

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Structures of Human Bruton'S Tyrosine Kinase in Active and Inactive Conformations Suggests A Mechanism of Activation For Tec Family Kinases. (pdb code 3k54). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structures of Human Bruton'S Tyrosine Kinase in Active and Inactive Conformations Suggests A Mechanism of Activation For Tec Family Kinases., PDB code: 3k54:

Chlorine binding site 1 out of 1 in 3k54

Go back to Chlorine Binding Sites List in 3k54
Chlorine binding site 1 out of 1 in the Structures of Human Bruton'S Tyrosine Kinase in Active and Inactive Conformations Suggests A Mechanism of Activation For Tec Family Kinases.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structures of Human Bruton'S Tyrosine Kinase in Active and Inactive Conformations Suggests A Mechanism of Activation For Tec Family Kinases. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1

b:52.4
occ:1.00
 CL A:1N11 0.0 52.4 1.0
C5 A:1N11 1.8 46.1 1.0
C6 A:1N11 2.7 46.2 1.0
C4 A:1N11 2.8 38.9 1.0
N2 A:1N11 3.0 32.7 1.0
O A:ALA428 3.5 22.9 1.0
CB A:LYS430 3.5 36.6 1.0
C3 A:1N11 3.5 34.4 1.0
O A:ILE472 3.6 26.7 1.0
N A:LYS430 3.6 33.1 1.0
OG1 A:THR474 3.7 22.5 1.0
C A:ALA428 3.7 24.5 1.0
O A:1N11 3.8 35.2 1.0
CG2 A:THR474 3.9 19.0 1.0
CB A:ALA428 3.9 22.6 1.0
N A:ILE429 4.0 26.4 1.0
C9 A:1N11 4.0 41.1 1.0
C7 A:1N11 4.0 45.3 1.0
C A:ILE429 4.1 30.6 1.0
CA A:LYS430 4.1 36.1 1.0
N A:THR474 4.2 18.8 1.0
CA A:ILE429 4.3 28.8 1.0
CB A:THR474 4.4 17.9 1.0
C A:ILE472 4.4 26.5 1.0
CA A:ALA428 4.5 23.1 1.0
C2 A:1N11 4.5 32.5 1.0
C8 A:1N11 4.5 41.8 1.0
CG1 A:VAL416 4.6 42.8 1.0
CG A:LYS430 4.8 37.0 1.0
CA A:ILE473 4.8 21.8 1.0
C A:ILE473 4.8 20.6 1.0
O A:ILE429 4.8 31.6 1.0
CD A:LYS430 4.9 40.2 1.0
CA A:THR474 4.9 18.9 1.0
N A:ILE473 4.9 24.0 1.0

Reference:

D.J.Marcotte, Y.T.Liu, R.M.Arduini, C.A.Hession, K.Miatkowski, C.P.Wildes, P.F.Cullen, V.Hong, B.T.Hopkins, E.Mertsching, T.J.Jenkins, M.J.Romanowski, D.P.Baker, L.F.Silvian. Structures of Human Bruton'S Tyrosine Kinase in Active and Inactive Conformations Suggest A Mechanism of Activation For Tec Family Kinases. Protein Sci. V. 19 429 2010.
ISSN: ISSN 0961-8368
PubMed: 20052711
DOI: 10.1002/PRO.321
Page generated: Fri Jul 11 06:51:59 2025

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