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Atomistry » Chlorine » PDB 3l2h-3lcc » 3l3a | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 3l2h-3lcc » 3l3a » |
Chlorine in PDB 3l3a: Bace-1 with the Aminopyridine Compound 32Enzymatic activity of Bace-1 with the Aminopyridine Compound 32
All present enzymatic activity of Bace-1 with the Aminopyridine Compound 32:
3.4.23.46; Protein crystallography data
The structure of Bace-1 with the Aminopyridine Compound 32, PDB code: 3l3a
was solved by
A.M.Olland,
R.Chopra,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Bace-1 with the Aminopyridine Compound 32
(pdb code 3l3a). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Bace-1 with the Aminopyridine Compound 32, PDB code: 3l3a: Chlorine binding site 1 out of 1 in 3l3aGo back to![]() ![]()
Chlorine binding site 1 out
of 1 in the Bace-1 with the Aminopyridine Compound 32
![]() Mono view ![]() Stereo pair view
Reference:
M.S.Malamas,
K.Barnes,
Y.Hui,
M.Johnson,
F.Lovering,
J.Condon,
W.Fobare,
W.Solvibile,
J.Turner,
Y.Hu,
E.S.Manas,
K.Fan,
A.Olland,
R.Chopra,
J.Bard,
M.N.Pangalos,
P.Reinhart,
A.J.Robichaud.
Novel Pyrrolyl 2-Aminopyridines As Potent and Selective Human Beta-Secretase (BACE1) Inhibitors. Bioorg.Med.Chem.Lett. V. 20 2068 2010.
Page generated: Sat Jul 20 23:09:42 2024
ISSN: ISSN 0960-894X PubMed: 20223661 DOI: 10.1016/J.BMCL.2010.02.075 |
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