Chlorine in PDB 3lc2: Crystal Structure of Thioacyl-Glyceraldehyde-3-Phosphate Dehydrogenase 1(Gapdh 1) From Methicillin Resistant Staphylococcus Aureus MRSA252

Enzymatic activity of Crystal Structure of Thioacyl-Glyceraldehyde-3-Phosphate Dehydrogenase 1(Gapdh 1) From Methicillin Resistant Staphylococcus Aureus MRSA252

All present enzymatic activity of Crystal Structure of Thioacyl-Glyceraldehyde-3-Phosphate Dehydrogenase 1(Gapdh 1) From Methicillin Resistant Staphylococcus Aureus MRSA252:
1.2.1.12;

Protein crystallography data

The structure of Crystal Structure of Thioacyl-Glyceraldehyde-3-Phosphate Dehydrogenase 1(Gapdh 1) From Methicillin Resistant Staphylococcus Aureus MRSA252, PDB code: 3lc2 was solved by S.Mukherjee, D.Dutta, B.Saha, A.K.Das, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	20.00 / 2.80
*Space group*	P 1 2₁ 1
*Cell size a, b, c (Å), α, β, γ (°)*	69.057, 103.025, 90.303, 90.00, 109.40, 90.00
*R / R_free (%)*	18.1 / 24.1

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Thioacyl-Glyceraldehyde-3-Phosphate Dehydrogenase 1(Gapdh 1) From Methicillin Resistant Staphylococcus Aureus MRSA252 (pdb code 3lc2). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Crystal Structure of Thioacyl-Glyceraldehyde-3-Phosphate Dehydrogenase 1(Gapdh 1) From Methicillin Resistant Staphylococcus Aureus MRSA252, PDB code: 3lc2:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in 3lc2

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Chlorine Binding Sites List in 3lc2

Chlorine binding site 1 out of 3 in the Crystal Structure of Thioacyl-Glyceraldehyde-3-Phosphate Dehydrogenase 1(Gapdh 1) From Methicillin Resistant Staphylococcus Aureus MRSA252

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Thioacyl-Glyceraldehyde-3-Phosphate Dehydrogenase 1(Gapdh 1) From Methicillin Resistant Staphylococcus Aureus MRSA252 within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
O:Cl338 b:46.0 occ:1.00	NH1	O:ARG198	3.7	40.2	1.0
	OG1	O:THR181	3.7	25.0	1.0
	C3	O:G3H337	3.8	29.9	1.0
	NH2	O:ARG234	3.9	24.4	1.0
	C2	O:G3H337	4.1	22.1	1.0
	O2	O:G3H337	4.3	25.0	1.0
	CB	O:THR181	4.3	22.0	1.0
	CG2	O:THR181	4.4	18.7	1.0
	CB	O:ASP183	4.6	26.6	1.0
	CZ	O:ARG198	4.7	37.9	1.0
	NH2	O:ARG198	4.8	39.5	1.0
	O1P	O:G3H337	4.8	32.9	1.0
	OD2	O:ASP183	4.9	43.7	1.0
	NH1	O:ARG234	4.9	26.4	1.0
	CZ	O:ARG234	4.9	25.9	1.0

Chlorine binding site 2 out of 3 in 3lc2

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Chlorine Binding Sites List in 3lc2

Chlorine binding site 2 out of 3 in the Crystal Structure of Thioacyl-Glyceraldehyde-3-Phosphate Dehydrogenase 1(Gapdh 1) From Methicillin Resistant Staphylococcus Aureus MRSA252

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Thioacyl-Glyceraldehyde-3-Phosphate Dehydrogenase 1(Gapdh 1) From Methicillin Resistant Staphylococcus Aureus MRSA252 within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
Q:Cl338 b:36.8 occ:1.00	OG1	Q:THR181	3.7	26.4	1.0
	C3	Q:G3H337	3.8	36.1	1.0
	NH1	Q:ARG198	3.8	43.2	1.0
	NH2	Q:ARG234	3.9	24.8	1.0
	C2	Q:G3H337	4.1	32.1	1.0
	O2	Q:G3H337	4.2	32.0	1.0
	CB	Q:THR181	4.2	22.4	1.0
	CG2	Q:THR181	4.3	18.9	1.0
	CB	Q:ASP183	4.6	27.4	1.0
	O1P	Q:G3H337	4.9	38.0	1.0
	CZ	Q:ARG198	4.9	39.2	1.0
	NH2	Q:ARG198	4.9	40.2	1.0
	CZ	Q:ARG234	4.9	27.2	1.0
	NH1	Q:ARG234	4.9	27.9	1.0

Chlorine binding site 3 out of 3 in 3lc2

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Chlorine Binding Sites List in 3lc2

Chlorine binding site 3 out of 3 in the Crystal Structure of Thioacyl-Glyceraldehyde-3-Phosphate Dehydrogenase 1(Gapdh 1) From Methicillin Resistant Staphylococcus Aureus MRSA252

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Thioacyl-Glyceraldehyde-3-Phosphate Dehydrogenase 1(Gapdh 1) From Methicillin Resistant Staphylococcus Aureus MRSA252 within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
R:Cl338 b:45.7 occ:1.00	OG1	R:THR181	3.9	26.8	1.0
	NH1	R:ARG198	3.9	42.8	1.0
	NH2	R:ARG234	4.1	26.0	1.0
	C3	R:G3H337	4.1	36.7	1.0
	C2	R:G3H337	4.2	31.9	1.0
	O2	R:G3H337	4.3	26.3	1.0
	CB	R:THR181	4.5	22.5	1.0
	CG2	R:THR181	4.6	18.7	1.0
	CB	R:ASP183	4.6	26.5	1.0
	CZ	R:ARG198	4.9	40.0	1.0
	NH2	R:ARG198	4.9	39.9	1.0

Reference:

S.Mukherjee, D.Dutta, B.Saha, A.K.Das. Crystal Structure of Glyceraldehyde-3-Phosphate Dehydrogenase 1 From Methicillin-Resistant Staphylococcus Aureus MRSA252 Provides Novel Insights Into Substrate Binding and Catalytic Mechanism. J.Mol.Biol. V. 401 949 2010.
ISSN: ISSN 0022-2836
PubMed: 20620151
DOI: 10.1016/J.JMB.2010.07.002

Page generated: Fri Jul 11 07:25:35 2025

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