Chlorine in PDB 3mxo: Crystal Structure Oh Human Phosphoglycerate Mutase Family Member 5 (PGAM5)

All present enzymatic activity of Crystal Structure Oh Human Phosphoglycerate Mutase Family Member 5 (PGAM5):
3.1.3.16;

The structure of Crystal Structure Oh Human Phosphoglycerate Mutase Family Member 5 (PGAM5), PDB code: 3mxo was solved by A.Chaikuad, I.Alfano, S.Picaud, P.Filippakopoulos, A.Barr, F.Von Delft, C.H.Arrowsmith, A.M.Edwards, J.Weigelt, C.Bountra, K.Takeda, H.Ichijo, S.Knapp, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.48 / 1.70
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	70.602, 70.946, 81.476, 90.00, 90.00, 90.00
R / Rfree (%)	16.8 / 20.3

The binding sites of Chlorine atom in the Crystal Structure Oh Human Phosphoglycerate Mutase Family Member 5 (PGAM5) (pdb code 3mxo). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure Oh Human Phosphoglycerate Mutase Family Member 5 (PGAM5), PDB code: 3mxo:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure Oh Human Phosphoglycerate Mutase Family Member 5 (PGAM5)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure Oh Human Phosphoglycerate Mutase Family Member 5 (PGAM5) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl2 b:26.9 occ:1.00 OG A:SER148 3.0 26.3 1.0 CB A:SER148 3.4 28.1 1.0 NE A:ARG152 3.4 27.1 1.0 NH2 A:ARG152 3.6 32.2 1.0 CD2 A:HIS230 3.7 22.4 1.0 CB A:ALA153 3.7 21.5 1.0 N A:HIS230 3.8 22.3 1.0 C A:CYS229 3.8 19.2 1.0 CB A:HIS230 3.8 17.6 1.0 CA A:CYS229 3.9 20.2 1.0 CZ A:ARG152 3.9 32.2 1.0 CB A:MET150 4.0 26.8 1.0 SD A:MET150 4.1 43.0 1.0 CG A:HIS230 4.1 18.1 1.0 CD2 A:HIS105 4.1 23.3 1.0 O A:LEU175 4.2 25.6 1.0 CA A:HIS230 4.3 18.2 1.0 CG A:ARG152 4.3 25.7 1.0 O A:CYS229 4.3 19.8 1.0 CG A:MET150 4.3 37.1 1.0 CD A:ARG152 4.4 26.2 1.0 CB A:CYS229 4.5 22.9 1.0 N A:ALA153 4.8 26.7 1.0 CA A:ALA153 4.8 20.9 1.0 CG A:HIS105 4.9 21.4 1.0 CA A:SER148 4.9 23.8 1.0 NE2 A:HIS230 5.0 20.9 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure Oh Human Phosphoglycerate Mutase Family Member 5 (PGAM5)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure Oh Human Phosphoglycerate Mutase Family Member 5 (PGAM5) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl291 b:29.5 occ:1.00 OG B:SER148 3.0 21.3 1.0 NH2 B:ARG152 3.3 35.7 1.0 NE B:ARG152 3.3 28.2 1.0 CB B:SER148 3.4 22.2 1.0 CZ B:ARG152 3.7 41.0 1.0 CB B:HIS230 3.8 20.4 1.0 CB B:ALA153 3.8 18.4 1.0 C B:CYS229 3.9 17.5 1.0 CD2 B:HIS230 3.9 28.6 1.0 N B:HIS230 3.9 13.6 1.0 CA B:CYS229 3.9 16.3 1.0 CD2 B:HIS105 4.0 21.8 1.0 CB B:MET150 4.1 26.5 1.0 O B:LEU175 4.2 20.8 1.0 CG B:HIS230 4.2 20.6 1.0 CA B:HIS230 4.3 17.1 1.0 CG B:ARG152 4.3 20.6 1.0 SD B:MET150 4.3 46.7 1.0 CG B:MET150 4.4 34.6 1.0 O B:CYS229 4.4 19.3 1.0 CD B:ARG152 4.4 22.8 1.0 CB B:CYS229 4.7 20.5 1.0 CG B:HIS105 4.8 16.4 1.0 N B:ALA153 4.9 19.0 1.0 CA B:ALA153 4.9 17.2 1.0 NE2 B:HIS105 4.9 19.0 1.0 CA B:SER148 4.9 21.0 1.0

A.Chaikuad, P.Filippakopoulos, S.R.Marcsisin, S.Picaud, M.Schroder, S.Sekine, H.Ichijo, J.R.Engen, K.Takeda, S.Knapp. Structures of PGAM5 Provide Insight Into Active Site Plasticity and Multimeric Assembly. Structure 2017.
ISSN: ISSN 1878-4186
PubMed: 28648608
DOI: 10.1016/J.STR.2017.05.020