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Chlorine in PDB 3ovz: Cathepsin K in Complex with A Covalent Inhibitor with A Ketoamide Warhead
Enzymatic activity of Cathepsin K in Complex with A Covalent Inhibitor with A Ketoamide Warhead
All present enzymatic activity of Cathepsin K in Complex with A Covalent Inhibitor with A Ketoamide Warhead:
3.4.22.38;
3.4.22.38;
Protein crystallography data
The structure of Cathepsin K in Complex with A Covalent Inhibitor with A Ketoamide Warhead, PDB code: 3ovz
was solved by
X.Fradera,
M.Van Zeeland,
J.C.M.Uitdehaag,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 51.16 / 2.02 |
| Space group | P 43 21 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 55.741, 55.741, 128.916, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 24.4 / 30.8 |
Other elements in 3ovz:
The structure of Cathepsin K in Complex with A Covalent Inhibitor with A Ketoamide Warhead also contains other interesting chemical elements:
| Fluorine | (F) | 3 atoms |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Cathepsin K in Complex with A Covalent Inhibitor with A Ketoamide Warhead
(pdb code 3ovz). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Cathepsin K in Complex with A Covalent Inhibitor with A Ketoamide Warhead, PDB code: 3ovz:
In total only one binding site of Chlorine was determined in the Cathepsin K in Complex with A Covalent Inhibitor with A Ketoamide Warhead, PDB code: 3ovz:
Chlorine binding site 1 out of 1 in 3ovz
Go back to
Chlorine Binding Sites List in 3ovz
Chlorine binding site 1 out
of 1 in the Cathepsin K in Complex with A Covalent Inhibitor with A Ketoamide Warhead
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Cathepsin K in Complex with A Covalent Inhibitor with A Ketoamide Warhead within 5.0Å range:
|
Reference:
J.Cai,
J.Robinson,
S.Belshaw,
K.Everett,
X.Fradera,
M.Van Zeeland,
L.Van Berkom,
P.Van Rijnsbergen,
L.Popplestone,
M.Baugh,
M.Dempster,
J.Bruin,
W.Hamilton,
E.Kinghorn,
P.Westwood,
J.Kerr,
Z.Rankovic,
W.Arbuckle,
D.J.Bennett,
P.S.Jones,
C.Long,
I.Martin,
J.C.Uitdehaag,
T.Meulemans.
Trifluoromethylphenyl As P2 For Ketoamide-Based Cathepsin S Inhibitors. Bioorg.Med.Chem.Lett. V. 20 6890 2010.
ISSN: ISSN 0960-894X
PubMed: 21030256
DOI: 10.1016/J.BMCL.2010.10.012
Page generated: Fri Jul 11 08:53:42 2025
ISSN: ISSN 0960-894X
PubMed: 21030256
DOI: 10.1016/J.BMCL.2010.10.012
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