Chlorine in PDB 3p2x: Insulin Fibrillation Is the Janus Face of Induced Fit. A Chiaral Clamp Stabilizes the Native State at the Expense of Activity

The structure of Insulin Fibrillation Is the Janus Face of Induced Fit. A Chiaral Clamp Stabilizes the Native State at the Expense of Activity, PDB code: 3p2x was solved by Q.X.Hua, Z.L.Wan, K.Huang, S.Q.Hu, N.F.Phillip, W.H.Jia, J.Whittingham, G.G.Dodson, P.G.Katsoyannis, M.A.Weiss, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	32.38 / 2.00
Space group	H 3
Cell size a, b, c (Å), α, β, γ (°)	78.363, 78.363, 36.848, 90.00, 90.00, 120.00
R / Rfree (%)	22.9 / 31.4

The structure of Insulin Fibrillation Is the Janus Face of Induced Fit. A Chiaral Clamp Stabilizes the Native State at the Expense of Activity also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Chlorine atom in the Insulin Fibrillation Is the Janus Face of Induced Fit. A Chiaral Clamp Stabilizes the Native State at the Expense of Activity (pdb code 3p2x). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Insulin Fibrillation Is the Janus Face of Induced Fit. A Chiaral Clamp Stabilizes the Native State at the Expense of Activity, PDB code: 3p2x:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Insulin Fibrillation Is the Janus Face of Induced Fit. A Chiaral Clamp Stabilizes the Native State at the Expense of Activity


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Insulin Fibrillation Is the Janus Face of Induced Fit. A Chiaral Clamp Stabilizes the Native State at the Expense of Activity within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl32 b:47.6 occ:0.33 ZN B:ZN31 2.3 11.5 0.3 NE2 B:HIS10 3.7 31.3 1.0 CD2 B:HIS10 4.2 31.6 1.0 CE1 B:HIS10 4.9 31.6 1.0

Chlorine binding site 2 out of 2 in the Insulin Fibrillation Is the Janus Face of Induced Fit. A Chiaral Clamp Stabilizes the Native State at the Expense of Activity


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Insulin Fibrillation Is the Janus Face of Induced Fit. A Chiaral Clamp Stabilizes the Native State at the Expense of Activity within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl32 b:13.9 occ:0.33 ZN D:ZN31 2.3 11.3 0.3 NE2 D:HIS10 3.5 34.9 1.0 CB D:LEU6 3.6 39.0 1.0 CD2 D:HIS10 3.9 32.9 1.0 CD1 D:LEU6 3.9 39.1 1.0 CG D:LEU6 4.4 38.0 1.0 O D:LEU6 4.6 38.3 1.0 CE1 D:HIS10 4.7 36.8 1.0 C D:LEU6 4.7 37.3 1.0 CA D:LEU6 4.7 38.2 1.0

Q.X.Hua, Z.L.Wan, K.Huang, S.Q.Hu, N.F.Phillip, W.H.Jia, J.Whittingham, G.G.Dodson, P.G.Katsoyannis, M.A.Weiss. Insulin Fibrillation Is the Janus Face of Induced Fit. A Chiral Clamp Stabilizes the Native State at the Expense of Activity To Be Published.