Chlorine in PDB 3rov: Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus

The structure of Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus, PDB code: 3rov was solved by M.A.Weiss, Z.L.Wan, E.J.Dodson, M.Liu, B.Xu, Q.X.Hua, M.Turkenburg, J.Whittingham, S.H.Nakagawa, K.Huang, S.Q.Hu, W.H.Jia, S.H.Wang, J.Brange, J.Whittaker, P.Arvan, P.G.Katsoyannis, G.G.Dodson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	44.36 / 2.30
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	45.662, 61.772, 46.038, 90.00, 105.50, 90.00
R / Rfree (%)	21.8 / 30.7

The structure of Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Chlorine atom in the Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus (pdb code 3rov). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus, PDB code: 3rov:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl32 b:22.6 occ:1.00 ZN B:ZN31 2.4 23.7 1.0 NE2 J:HIS10 3.7 21.8 1.0 NE2 B:HIS10 3.7 25.6 1.0 NE2 F:HIS10 3.8 21.2 1.0 CB F:LEU6 3.9 20.3 1.0 CB B:LEU6 3.9 20.8 1.0 CD2 J:HIS10 3.9 21.9 1.0 CD1 F:LEU6 4.0 18.7 1.0 CD2 F:HIS10 4.1 19.8 1.0 CB J:LEU6 4.1 24.0 1.0 CD2 B:HIS10 4.2 24.1 1.0 CD1 B:LEU6 4.2 19.6 1.0 CD1 J:LEU6 4.3 24.6 1.0 CG F:LEU6 4.5 20.2 1.0 CG B:LEU6 4.7 22.4 1.0 OD1 B:ASN3 4.8 37.2 1.0 CE1 B:HIS10 4.8 24.0 1.0 CG J:LEU6 4.8 24.4 1.0 CE1 J:HIS10 4.9 20.9 1.0 CE1 F:HIS10 4.9 21.8 1.0 O B:LEU6 4.9 20.4 1.0 C B:LEU6 4.9 21.0 1.0 CA F:LEU6 5.0 21.3 1.0

Chlorine binding site 2 out of 2 in the Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus within 5.0Å range: probe atom residue distance (Å) B Occ H:Cl31 b:23.4 occ:1.00 ZN D:ZN31 2.5 25.8 1.0 NE2 H:HIS10 3.6 23.6 1.0 CG D:LEU6 3.8 40.8 1.0 CB L:LEU6 3.8 16.9 1.0 CB D:LEU6 3.8 36.1 1.0 CD2 D:LEU6 3.9 41.9 1.0 CB H:LEU6 3.9 17.9 1.0 CD1 L:LEU6 3.9 19.3 1.0 NE2 L:HIS10 3.9 13.1 1.0 NE2 D:HIS10 4.0 16.4 1.0 CD1 H:LEU6 4.0 15.9 1.0 CD2 D:HIS10 4.2 13.6 1.0 CD2 L:HIS10 4.2 17.9 1.0 CD2 H:HIS10 4.2 24.6 1.0 CG L:LEU6 4.5 19.3 1.0 CE1 H:HIS10 4.6 22.4 1.0 CG H:LEU6 4.6 18.4 1.0 C D:LEU6 4.8 29.8 1.0 C H:LEU6 4.8 22.9 1.0 O H:LEU6 4.8 25.0 1.0 CA D:LEU6 4.9 34.6 1.0 CA L:LEU6 4.9 18.1 1.0 O D:LEU6 4.9 28.4 1.0 C L:LEU6 4.9 18.3 1.0 CA H:LEU6 5.0 23.7 1.0

M.A.Weiss, Z.L.Wan, E.J.Dodson, M.Liu, B.Xu, Q.X.Hua, M.Turkenburg, J.Whittingham, S.H.Nakagawa, K.Huang, S.Q.Hu, W.H.Jia, S.H.Wang, J.Brange, J.Whittaker, P.Arvan, P.G.Katsoyannis, G.G.Dodson. Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus To Be Published.