Chlorine in PDB 3s3w: Structure of Chicken Acid-Sensing Ion Channel 1 at 2.6 A Resolution and pH 7.5

The structure of Structure of Chicken Acid-Sensing Ion Channel 1 at 2.6 A Resolution and pH 7.5, PDB code: 3s3w was solved by R.J.P.Dawson, J.Benz, P.Stohler, T.Tetaz, C.Joseph, S.Huber, G.Schmid, D.Huegin, P.Pflimlin, G.Trube, M.G.Rudolph, M.Hennig, A.Ruf, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.94 / 2.60
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	110.469, 142.689, 159.736, 90.00, 90.00, 90.00
R / Rfree (%)	21.2 / 23.6

The binding sites of Chlorine atom in the Structure of Chicken Acid-Sensing Ion Channel 1 at 2.6 A Resolution and pH 7.5 (pdb code 3s3w). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Structure of Chicken Acid-Sensing Ion Channel 1 at 2.6 A Resolution and pH 7.5, PDB code: 3s3w:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in the Structure of Chicken Acid-Sensing Ion Channel 1 at 2.6 A Resolution and pH 7.5


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Chicken Acid-Sensing Ion Channel 1 at 2.6 A Resolution and pH 7.5 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl464 b:59.8 occ:1.00 OE2 A:GLU314 3.0 50.9 1.0 NE A:ARG310 3.3 47.4 1.0 NZ C:LYS212 3.4 40.2 1.0 NH1 A:ARG310 3.4 36.2 1.0 CG A:GLU314 3.7 41.8 1.0 CD A:GLU314 3.8 56.7 1.0 CZ A:ARG310 3.8 46.5 1.0 CB A:CYS360 3.9 46.4 1.0 CD C:LYS212 3.9 42.2 1.0 O A:LEU352 4.1 47.4 1.0 CE C:LYS212 4.2 40.8 1.0 CB A:LEU352 4.2 46.4 1.0 CB A:ARG310 4.2 36.0 1.0 CG1 A:VAL353 4.2 37.8 1.0 C A:LEU352 4.3 53.3 1.0 CG A:ARG310 4.4 37.1 1.0 CD A:ARG310 4.5 38.6 1.0 SG A:CYS360 4.5 0.6 1.0 O A:CYS360 4.6 82.7 1.0 N A:VAL353 4.6 27.6 1.0 CA A:VAL353 4.7 39.5 1.0 O A:ARG310 4.8 44.7 1.0 CA A:ARG310 4.8 48.8 1.0 CA A:LEU352 4.9 42.3 1.0 OE1 A:GLU314 5.0 38.6 1.0

Chlorine binding site 2 out of 3 in the Structure of Chicken Acid-Sensing Ion Channel 1 at 2.6 A Resolution and pH 7.5


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of Chicken Acid-Sensing Ion Channel 1 at 2.6 A Resolution and pH 7.5 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl464 b:51.2 occ:1.00 OE2 B:GLU314 2.9 50.3 1.0 NE B:ARG310 3.2 36.8 1.0 NZ A:LYS212 3.3 36.3 1.0 NH1 B:ARG310 3.4 34.4 1.0 CG B:GLU314 3.7 35.8 1.0 CZ B:ARG310 3.7 41.0 1.0 CD B:GLU314 3.8 54.2 1.0 CD A:LYS212 3.9 43.2 1.0 CB B:CYS360 3.9 37.9 1.0 CB B:ARG310 4.1 23.7 1.0 CE A:LYS212 4.1 37.5 1.0 O B:LEU352 4.2 49.8 1.0 CG B:ARG310 4.3 40.7 1.0 CG1 B:VAL353 4.3 30.9 1.0 CD B:ARG310 4.3 36.5 1.0 CB B:LEU352 4.4 40.7 1.0 C B:LEU352 4.4 53.1 1.0 O B:CYS360 4.6 77.1 1.0 SG B:CYS360 4.6 92.1 1.0 N B:VAL353 4.7 30.0 1.0 CA B:ARG310 4.7 49.2 1.0 O B:ARG310 4.8 40.0 1.0 CA B:VAL353 4.8 35.1 1.0 OE1 B:GLU314 5.0 48.3 1.0

Chlorine binding site 3 out of 3 in the Structure of Chicken Acid-Sensing Ion Channel 1 at 2.6 A Resolution and pH 7.5


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Structure of Chicken Acid-Sensing Ion Channel 1 at 2.6 A Resolution and pH 7.5 within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl464 b:55.1 occ:1.00 OE2 C:GLU314 3.0 53.1 1.0 NZ B:LYS212 3.3 38.4 1.0 NE C:ARG310 3.4 40.0 1.0 NH1 C:ARG310 3.5 40.5 1.0 CG C:GLU314 3.6 36.0 1.0 CB C:CYS360 3.8 48.4 1.0 CD C:GLU314 3.8 50.4 1.0 CD B:LYS212 3.9 41.4 1.0 CZ C:ARG310 3.9 41.8 1.0 O C:LEU352 4.1 57.8 1.0 CE B:LYS212 4.1 43.4 1.0 CB C:LEU352 4.2 47.2 1.0 CB C:ARG310 4.2 34.5 1.0 C C:LEU352 4.3 52.1 1.0 CG1 C:VAL353 4.3 35.6 1.0 CG C:ARG310 4.4 28.1 1.0 SG C:CYS360 4.4 94.9 1.0 CD C:ARG310 4.5 42.2 1.0 O C:CYS360 4.5 88.7 1.0 N C:VAL353 4.7 39.2 1.0 CA C:VAL353 4.7 47.7 1.0 O C:ARG310 4.8 41.2 1.0 CA C:ARG310 4.8 46.0 1.0 CA C:LEU352 4.9 38.8 1.0 OE1 C:GLU314 5.0 38.4 1.0

R.J.Dawson, J.Benz, P.Stohler, T.Tetaz, C.Joseph, S.Huber, G.Schmid, D.Hugin, P.Pflimlin, G.Trube, M.G.Rudolph, M.Hennig, A.Ruf. Structure of the Acid-Sensing Ion Channel 1 in Complex with the Gating Modifier Psalmotoxin 1. Nat Commun V. 3 936 2012.
ISSN: ESSN 2041-1723
PubMed: 22760635
DOI: 10.1038/NCOMMS1917