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Chlorine in PDB 3sff: Crystal Structure of Human HDAC8 Inhibitor Complex, An Amino Acid Derived Inhibitor
Enzymatic activity of Crystal Structure of Human HDAC8 Inhibitor Complex, An Amino Acid Derived Inhibitor
All present enzymatic activity of Crystal Structure of Human HDAC8 Inhibitor Complex, An Amino Acid Derived Inhibitor:
3.5.1.98;
3.5.1.98;
Protein crystallography data
The structure of Crystal Structure of Human HDAC8 Inhibitor Complex, An Amino Acid Derived Inhibitor, PDB code: 3sff
was solved by
T.Stams,
B.Vash,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 29.00 / 2.00 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 57.812, 53.668, 61.338, 90.00, 108.99, 90.00 |
| R / Rfree (%) | 17.7 / 22.1 |
Other elements in 3sff:
The structure of Crystal Structure of Human HDAC8 Inhibitor Complex, An Amino Acid Derived Inhibitor also contains other interesting chemical elements:
| Fluorine | (F) | 2 atoms |
| Potassium | (K) | 2 atoms |
| Zinc | (Zn) | 1 atom |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Human HDAC8 Inhibitor Complex, An Amino Acid Derived Inhibitor
(pdb code 3sff). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Human HDAC8 Inhibitor Complex, An Amino Acid Derived Inhibitor, PDB code: 3sff:
In total only one binding site of Chlorine was determined in the Crystal Structure of Human HDAC8 Inhibitor Complex, An Amino Acid Derived Inhibitor, PDB code: 3sff:
Chlorine binding site 1 out of 1 in 3sff
Go back to
Chlorine Binding Sites List in 3sff
Chlorine binding site 1 out
of 1 in the Crystal Structure of Human HDAC8 Inhibitor Complex, An Amino Acid Derived Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of Human HDAC8 Inhibitor Complex, An Amino Acid Derived Inhibitor within 5.0Å range:
|
Reference:
L.Whitehead,
M.R.Dobler,
B.Radetich,
Y.Zhu,
P.W.Atadja,
T.Claiborne,
J.E.Grob,
A.Mcriner,
M.R.Pancost,
A.Patnaik,
W.Shao,
M.Shultz,
R.Tichkule,
R.A.Tommasi,
B.Vash,
P.Wang,
T.Stams.
Human Hdac Isoform Selectivity Achieved Via Exploitation of the Acetate Release Channel with Structurally Unique Small Molecule Inhibitors. Bioorg.Med.Chem. V. 19 4626 2011.
ISSN: ISSN 0968-0896
PubMed: 21723733
DOI: 10.1016/J.BMC.2011.06.030
Page generated: Sun Jul 21 04:28:22 2024
ISSN: ISSN 0968-0896
PubMed: 21723733
DOI: 10.1016/J.BMC.2011.06.030
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