Chlorine in PDB 3spa: Crystal Structure of Human Mitochondrial Rna Polymerase

All present enzymatic activity of Crystal Structure of Human Mitochondrial Rna Polymerase:
2.7.7.6;

The structure of Crystal Structure of Human Mitochondrial Rna Polymerase, PDB code: 3spa was solved by R.Ringel, M.Sologub, Y.I.Morozov, D.Litonin, P.Cramer, D.Temiakov, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	58.13 / 2.50
Space group	I 41
Cell size a, b, c (Å), α, β, γ (°)	211.258, 211.258, 60.461, 90.00, 90.00, 90.00
R / Rfree (%)	18.6 / 23.1

The binding sites of Chlorine atom in the Crystal Structure of Human Mitochondrial Rna Polymerase (pdb code 3spa). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the Crystal Structure of Human Mitochondrial Rna Polymerase, PDB code: 3spa:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;

Chlorine binding site 1 out of 5 in the Crystal Structure of Human Mitochondrial Rna Polymerase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Mitochondrial Rna Polymerase within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1231 b:0.8 occ:1.00 N A:GLY830 3.4 63.1 1.0 CA A:GLN829 4.0 62.0 1.0 O A:HOH1258 4.1 73.0 1.0 O A:GLY830 4.2 65.7 1.0 C A:GLN829 4.2 65.3 1.0 CB A:HIS390 4.2 73.0 1.0 CA A:GLY830 4.2 62.2 1.0 CE1 A:HIS916 4.3 61.0 1.0 CG1 A:VAL914 4.4 61.8 1.0 ND1 A:HIS390 4.5 76.5 1.0 O A:ALA828 4.5 67.4 1.0 CG A:HIS390 4.5 74.6 1.0 NE2 A:HIS916 4.6 62.0 1.0 CG A:GLN829 4.6 80.2 1.0 C A:GLY830 4.6 64.8 1.0 CB A:GLN829 4.8 63.7 1.0

Chlorine binding site 2 out of 5 in the Crystal Structure of Human Mitochondrial Rna Polymerase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Human Mitochondrial Rna Polymerase within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1232 b:0.6 occ:1.00 CB A:MET406 3.6 80.8 1.0 CA A:MET406 3.6 78.1 1.0 CG A:MET406 3.7 85.7 1.0 N A:MET406 4.1 79.3 1.0 ND1 A:HIS405 4.1 90.3 1.0 O A:LYS402 4.6 74.7 1.0 CG1 A:VAL412 4.6 80.8 1.0 C A:HIS405 4.7 83.7 1.0 CE1 A:HIS405 4.9 91.1 1.0 CE A:MET406 4.9 88.9 1.0 C A:MET406 5.0 77.1 1.0 O A:HIS405 5.0 83.2 1.0

Chlorine binding site 3 out of 5 in the Crystal Structure of Human Mitochondrial Rna Polymerase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Human Mitochondrial Rna Polymerase within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl3 b:0.1 occ:1.00 NZ A:LYS402 3.1 0.5 1.0 NH2 A:ARG792 3.3 0.5 1.0 NH1 A:ARG792 3.7 99.6 1.0 CZ A:ARG792 3.8 0.9 1.0 CE A:LYS402 4.0 0.9 1.0 CD A:LYS402 4.7 93.8 1.0 NE A:ARG792 4.9 93.5 1.0

Chlorine binding site 4 out of 5 in the Crystal Structure of Human Mitochondrial Rna Polymerase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of Human Mitochondrial Rna Polymerase within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl4 b:0.0 occ:1.00 NH2 A:ARG518 3.1 91.2 1.0 O A:HOH1257 3.4 72.2 1.0 CA A:ALA409 3.6 69.3 1.0 NH1 A:ARG518 3.7 0.9 1.0 O A:LEU408 3.7 75.2 1.0 CZ A:ARG518 3.8 0.5 1.0 N A:ALA409 3.9 70.2 1.0 C A:LEU408 3.9 74.8 1.0 CB A:ALA409 4.1 69.2 1.0 O A:HOH1283 4.5 73.8 1.0 CB A:LEU408 4.7 73.3 1.0 C A:ALA409 4.9 74.4 1.0 CA A:LEU408 4.9 71.8 1.0

Chlorine binding site 5 out of 5 in the Crystal Structure of Human Mitochondrial Rna Polymerase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Crystal Structure of Human Mitochondrial Rna Polymerase within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl5 b:97.3 occ:1.00 NH1 A:ARG858 3.2 53.4 1.0 CD A:ARG858 3.6 75.8 1.0 CG A:ARG858 3.7 75.4 1.0 CB A:ARG858 4.0 64.6 1.0 CZ A:ARG858 4.2 79.2 1.0 NE A:ARG858 4.3 70.2 1.0

R.Ringel, M.Sologub, Y.I.Morozov, D.Litonin, P.Cramer, D.Temiakov. Structure of Human Mitochondrial Rna Polymerase Nature V. 478 269 2011.
ISSN: ISSN 0028-0836
PubMed: 21947009
DOI: 10.1038/NATURE10435