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Atomistry » Chlorine » PDB 3th4-3tnn » 3thb » |
Chlorine in PDB 3thb: Structure of PLK1 Kinase Domain in Complex with A Benzolactam-Derived InhibitorEnzymatic activity of Structure of PLK1 Kinase Domain in Complex with A Benzolactam-Derived Inhibitor
All present enzymatic activity of Structure of PLK1 Kinase Domain in Complex with A Benzolactam-Derived Inhibitor:
2.7.11.21; Protein crystallography data
The structure of Structure of PLK1 Kinase Domain in Complex with A Benzolactam-Derived Inhibitor, PDB code: 3thb
was solved by
M.D.Sintchak,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3thb:
The structure of Structure of PLK1 Kinase Domain in Complex with A Benzolactam-Derived Inhibitor also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Structure of PLK1 Kinase Domain in Complex with A Benzolactam-Derived Inhibitor
(pdb code 3thb). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structure of PLK1 Kinase Domain in Complex with A Benzolactam-Derived Inhibitor, PDB code: 3thb: Chlorine binding site 1 out of 1 in 3thbGo back to![]() ![]()
Chlorine binding site 1 out
of 1 in the Structure of PLK1 Kinase Domain in Complex with A Benzolactam-Derived Inhibitor
![]() Mono view ![]() Stereo pair view
Reference:
M.O.Duffey,
T.J.Vos,
R.Adams,
J.Alley,
J.Anthony,
C.Barrett,
I.Bharathan,
D.Bowman,
N.J.Bump,
R.Chau,
C.Cullis,
D.L.Driscoll,
A.Elder,
N.Forsyth,
J.Frazer,
J.Guo,
L.Guo,
M.L.Hyer,
D.Janowick,
B.Kulkarni,
S.J.Lai,
K.Lasky,
G.Li,
J.Li,
D.Liao,
J.Little,
B.Peng,
M.G.Qian,
D.J.Reynolds,
M.Rezaei,
M.P.Scott,
T.B.Sells,
V.Shinde,
Q.J.Shi,
M.D.Sintchak,
F.Soucy,
K.T.Sprott,
S.G.Stroud,
M.Nestor,
I.Visiers,
G.Weatherhead,
Y.Ye,
N.D'amore.
Discovery of A Potent and Orally Bioavailable Benzolactam-Derived Inhibitor of Polo-Like Kinase 1 (MLN0905). J.Med.Chem. V. 55 197 2012.
Page generated: Sun Jul 21 05:12:41 2024
ISSN: ISSN 0022-2623 PubMed: 22070629 DOI: 10.1021/JM2011172 |
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