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Chlorine in PDB 3uxe: Design, Synthesis and Biological Evaluation of Potent Quinoline and Pyrroloquinoline Ammosamide Analogues As Inhibitors For Quinone Reductase 2
Enzymatic activity of Design, Synthesis and Biological Evaluation of Potent Quinoline and Pyrroloquinoline Ammosamide Analogues As Inhibitors For Quinone Reductase 2
All present enzymatic activity of Design, Synthesis and Biological Evaluation of Potent Quinoline and Pyrroloquinoline Ammosamide Analogues As Inhibitors For Quinone Reductase 2:
1.10.99.2;
1.10.99.2;
Protein crystallography data
The structure of Design, Synthesis and Biological Evaluation of Potent Quinoline and Pyrroloquinoline Ammosamide Analogues As Inhibitors For Quinone Reductase 2, PDB code: 3uxe
was solved by
N.P.Reddy,
K.C.Jensen,
A.D.Mesecar,
P.E.Fanwick,
M.Cushman,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 19.68 / 1.50 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 56.553, 83.953, 106.815, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 17.7 / 19.7 |
Other elements in 3uxe:
The structure of Design, Synthesis and Biological Evaluation of Potent Quinoline and Pyrroloquinoline Ammosamide Analogues As Inhibitors For Quinone Reductase 2 also contains other interesting chemical elements:
| Zinc | (Zn) | 2 atoms |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Design, Synthesis and Biological Evaluation of Potent Quinoline and Pyrroloquinoline Ammosamide Analogues As Inhibitors For Quinone Reductase 2
(pdb code 3uxe). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Design, Synthesis and Biological Evaluation of Potent Quinoline and Pyrroloquinoline Ammosamide Analogues As Inhibitors For Quinone Reductase 2, PDB code: 3uxe:
Jump to Chlorine binding site number: 1; 2;
In total 2 binding sites of Chlorine where determined in the Design, Synthesis and Biological Evaluation of Potent Quinoline and Pyrroloquinoline Ammosamide Analogues As Inhibitors For Quinone Reductase 2, PDB code: 3uxe:
Jump to Chlorine binding site number: 1; 2;
Chlorine binding site 1 out of 2 in 3uxe
Go back to
Chlorine Binding Sites List in 3uxe
Chlorine binding site 1 out
of 2 in the Design, Synthesis and Biological Evaluation of Potent Quinoline and Pyrroloquinoline Ammosamide Analogues As Inhibitors For Quinone Reductase 2
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Design, Synthesis and Biological Evaluation of Potent Quinoline and Pyrroloquinoline Ammosamide Analogues As Inhibitors For Quinone Reductase 2 within 5.0Å range:
|
Chlorine binding site 2 out of 2 in 3uxe
Go back to
Chlorine Binding Sites List in 3uxe
Chlorine binding site 2 out
of 2 in the Design, Synthesis and Biological Evaluation of Potent Quinoline and Pyrroloquinoline Ammosamide Analogues As Inhibitors For Quinone Reductase 2
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Design, Synthesis and Biological Evaluation of Potent Quinoline and Pyrroloquinoline Ammosamide Analogues As Inhibitors For Quinone Reductase 2 within 5.0Å range:
|
Reference:
P.V.Reddy,
K.C.Jensen,
A.D.Mesecar,
P.E.Fanwick,
M.Cushman.
Design, Synthesis, and Biological Evaluation of Potent Quinoline and Pyrroloquinoline Ammosamide Analogues As Inhibitors of Quinone Reductase 2. J.Med.Chem. V. 55 367 2012.
ISSN: ISSN 0022-2623
PubMed: 22206487
DOI: 10.1021/JM201251C
Page generated: Fri Jul 11 11:31:45 2025
ISSN: ISSN 0022-2623
PubMed: 22206487
DOI: 10.1021/JM201251C
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