Chlorine in PDB 3vw8: Crystal Structure of Human C-Met Kinase Domain with Its Inhibitor

All present enzymatic activity of Crystal Structure of Human C-Met Kinase Domain with Its Inhibitor:
2.7.10.1;

The structure of Crystal Structure of Human C-Met Kinase Domain with Its Inhibitor, PDB code: 3vw8 was solved by S.Matsumoto, N.Miyamoto, T.Hirayama, H.Oki, K.Okada, M.Tawada, H.Iwata, H.Miki, K.Nakamura, A.Hori, S.Imamura, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 2.10
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	42.690, 78.786, 89.969, 90.00, 90.00, 90.00
R / Rfree (%)	21.2 / 25.9

The binding sites of Chlorine atom in the Crystal Structure of Human C-Met Kinase Domain with Its Inhibitor (pdb code 3vw8). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Human C-Met Kinase Domain with Its Inhibitor, PDB code: 3vw8:

Chlorine binding site 1 out of 1 in the Crystal Structure of Human C-Met Kinase Domain with Its Inhibitor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human C-Met Kinase Domain with Its Inhibitor within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1402 b:24.1 occ:1.00 O A:HOH1514 3.2 28.4 1.0 N A:GLY1346 3.3 29.8 1.0 N A:GLU1347 3.3 33.2 1.0 N A:HIS1348 3.3 35.2 1.0 CA A:GLY1346 3.3 31.0 1.0 N A:LYS1179 3.4 26.9 1.0 CD1 A:PHE1344 3.7 24.0 1.0 C A:GLY1346 3.7 32.0 1.0 N A:VAL1178 3.7 27.8 1.0 CB A:HIS1348 3.8 35.8 1.0 CB A:THR1177 3.8 28.7 1.0 CB A:VAL1178 3.9 27.3 1.0 CB A:LYS1179 3.9 27.8 1.0 CB A:PHE1344 3.9 25.1 1.0 O A:HIS1348 4.0 36.2 1.0 CA A:HIS1348 4.0 35.6 1.0 CD2 A:HIS1348 4.1 36.2 1.0 OG1 A:THR1177 4.1 28.4 1.0 CA A:VAL1178 4.2 27.5 1.0 CG A:PHE1344 4.2 25.0 1.0 C A:VAL1178 4.3 27.3 1.0 CA A:LYS1179 4.3 27.0 1.0 CG A:HIS1348 4.3 36.1 1.0 C A:GLU1347 4.3 34.7 1.0 CA A:GLU1347 4.4 34.3 1.0 N A:ILE1345 4.4 27.4 1.0 C A:HIS1348 4.4 36.2 1.0 C A:ILE1345 4.5 29.4 1.0 C A:THR1177 4.5 28.4 1.0 CE1 A:PHE1344 4.6 23.7 1.0 CG2 A:VAL1178 4.6 27.9 1.0 CG2 A:THR1177 4.7 28.1 1.0 O A:GLY1346 4.7 31.5 1.0 CA A:THR1177 4.7 28.9 1.0 CG1 A:VAL1178 4.9 26.5 1.0 CA A:PHE1344 4.9 25.5 1.0

S.Matsumoto, N.Miyamoto, T.Hirayama, H.Oki, K.Okada, M.Tawada, H.Iwata, K.Nakamura, S.Yamasaki, H.Miki, A.Hori, S.Imamura. Structure-Based Design, Synthesis, and Evaluation of Imidazo[1,2-B]Pyridazine and Imidazo[1,2-A]Pyridine Derivatives As Novel Dual C-Met and VEGFR2 Kinase Inhibitors. Bioorg.Med.Chem. 2013.
ISSN: ESSN 1464-3391
PubMed: 24216091
DOI: 10.1016/J.BMC.2013.10.028