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Atomistry » Chlorine » PDB 3vwi-3w96 » 3w2o | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 3vwi-3w96 » 3w2o » |
Chlorine in PDB 3w2o: Egfr Kinase Domain T790M/L858R Mutant with Tak-285Enzymatic activity of Egfr Kinase Domain T790M/L858R Mutant with Tak-285
All present enzymatic activity of Egfr Kinase Domain T790M/L858R Mutant with Tak-285:
2.7.10.1; Protein crystallography data
The structure of Egfr Kinase Domain T790M/L858R Mutant with Tak-285, PDB code: 3w2o
was solved by
S.Sogabe,
Y.Kawakita,
S.Igaki,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3w2o:
The structure of Egfr Kinase Domain T790M/L858R Mutant with Tak-285 also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Egfr Kinase Domain T790M/L858R Mutant with Tak-285
(pdb code 3w2o). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Egfr Kinase Domain T790M/L858R Mutant with Tak-285, PDB code: 3w2o: Chlorine binding site 1 out of 1 in 3w2oGo back to![]() ![]()
Chlorine binding site 1 out
of 1 in the Egfr Kinase Domain T790M/L858R Mutant with Tak-285
![]() Mono view ![]() Stereo pair view
Reference:
S.Sogabe,
Y.Kawakita,
S.Igaki,
H.Iwata,
H.Miki,
D.R.Cary,
T.Takagi,
S.Takagi,
Y.Ohta,
T.Ishikawa.
Structure-Based Approach For the Discovery of Pyrrolo[3,2-D]Pyrimidine-Based Egfr T790M/L858R Mutant Inhibitors. Acs Med.Chem.Lett. V. 4 201 2013.
Page generated: Sun Jul 21 07:20:34 2024
ISSN: ISSN 1948-5875 PubMed: 24900643 DOI: 10.1021/ML300327Z |
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