Chlorine in PDB 4a26: The Crystal Structure of Leishmania Major N5,N10- Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase

Enzymatic activity of The Crystal Structure of Leishmania Major N5,N10- Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase

All present enzymatic activity of The Crystal Structure of Leishmania Major N5,N10- Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase:
1.5.1.5; 3.5.4.9;

Protein crystallography data

The structure of The Crystal Structure of Leishmania Major N5,N10- Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase, PDB code: 4a26 was solved by T.C.Eadsforth, S.Cameron, W.N.Hunter, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	40.00 / 2.70
*Space group*	C 2 2 2₁
*Cell size a, b, c (Å), α, β, γ (°)*	117.220, 220.080, 56.310, 90.00, 90.00, 90.00
*R / R_free (%)*	23.056 / 28.998

Chlorine Binding Sites:

The binding sites of Chlorine atom in the The Crystal Structure of Leishmania Major N5,N10- Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase (pdb code 4a26). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the The Crystal Structure of Leishmania Major N5,N10- Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase, PDB code: 4a26:

Chlorine binding site 1 out of 1 in 4a26

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Chlorine Binding Sites List in 4a26

Chlorine binding site 1 out of 1 in the The Crystal Structure of Leishmania Major N5,N10- Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of The Crystal Structure of Leishmania Major N5,N10- Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
B:Cl1297 b:47.2 occ:1.00	NE	B:ARG171	3.3	33.2	1.0
	NZ	A:LYS136	3.3	51.4	1.0
	N	B:SER195	3.6	30.9	1.0
	CB	B:HIS194	3.7	27.6	1.0
	CG	B:ARG171	3.8	31.9	1.0
	OG	B:SER195	3.9	35.1	1.0
	NH2	B:ARG171	4.0	35.5	1.0
	CB	B:SER195	4.0	34.8	1.0
	CZ	B:ARG171	4.1	34.3	1.0
	CD	B:ARG171	4.1	31.9	1.0
	CA	B:HIS194	4.3	28.0	1.0
	CA	B:SER195	4.5	32.8	1.0
	C	B:HIS194	4.5	29.4	1.0
	CE	A:LYS136	4.7	52.8	1.0
	CG	B:HIS194	4.8	26.3	1.0

Reference:

T.C.Eadsforth, S.Cameron, W.N.Hunter. The Crystal Structure of Leishmania Major N(5),N(10)- Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase and Assessment of A Potential Drug Target. Mol.Biochem.Parasitol. V. 181 178 2012.
ISSN: ISSN 0166-6851
PubMed: 22108435
DOI: 10.1016/J.MOLBIOPARA.2011.11.004

Page generated: Sun Jul 21 08:51:28 2024

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