Chlorine in PDB 4air: Leishmania Major Cysteine Synthase

All present enzymatic activity of Leishmania Major Cysteine Synthase:
2.5.1.47;

The structure of Leishmania Major Cysteine Synthase, PDB code: 4air was solved by P.K.Fyfe, G.D.Westrop, G.H.Coombs, W.N.Hunter, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.00 / 1.80
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	48.958, 86.325, 134.019, 90.00, 90.00, 90.00
R / Rfree (%)	15.663 / 20.826

The binding sites of Chlorine atom in the Leishmania Major Cysteine Synthase (pdb code 4air). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Leishmania Major Cysteine Synthase, PDB code: 4air:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Leishmania Major Cysteine Synthase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Leishmania Major Cysteine Synthase within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1428 b:13.1 occ:1.00 O A:HOH2317 3.1 14.2 1.0 N A:GLY275 3.2 11.9 1.0 N A:GLY272 3.2 11.7 1.0 N A:SER302 3.4 11.1 1.0 CD A:PRO301 3.4 11.2 1.0 CA A:GLY272 3.5 12.0 1.0 O A:SER302 3.5 10.4 1.0 C A:GLY272 3.6 12.7 1.0 O A:GLY272 3.7 13.1 1.0 CA A:GLY275 3.7 12.5 1.0 CB A:SER302 3.8 13.3 1.0 N A:PRO301 3.9 11.5 1.0 CB A:CYS271 4.0 12.7 1.0 CA A:SER302 4.0 11.5 1.0 CB A:PRO301 4.0 11.1 1.0 CB A:SER274 4.0 14.2 1.0 N A:SER274 4.1 13.1 1.0 CG A:PRO301 4.1 11.2 1.0 OG A:SER302 4.1 15.2 1.0 C A:SER274 4.1 12.8 1.0 C A:SER302 4.2 11.1 1.0 C A:PRO301 4.2 11.2 1.0 CA A:PRO301 4.2 11.1 1.0 C A:CYS271 4.3 12.1 1.0 CA A:SER274 4.3 13.4 1.0 N A:PHE273 4.3 13.6 1.0 OXT A:FGA1330 4.4 16.2 1.0 SG A:CYS271 4.5 14.9 1.0 CA A:CYS271 4.6 12.3 1.0 C A:ILE300 4.7 11.0 1.0 CG2 A:ILE300 4.8 11.4 1.0 C A:PHE273 4.8 13.5 1.0

Chlorine binding site 2 out of 2 in the Leishmania Major Cysteine Synthase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Leishmania Major Cysteine Synthase within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1428 b:18.4 occ:1.00 OG B:SER302 2.9 11.0 0.5 O B:HOH2284 3.1 29.2 1.0 N B:GLY272 3.2 13.2 1.0 N B:GLY275 3.2 12.8 1.0 OG B:SER274 3.2 15.3 0.5 N B:SER302 3.3 11.1 0.5 N B:SER302 3.3 11.0 0.5 O B:SER302 3.5 10.3 0.5 CA B:GLY272 3.5 12.7 1.0 O B:SER302 3.6 10.4 0.5 CD B:PRO301 3.6 11.1 1.0 C B:GLY272 3.6 13.4 1.0 CB B:SER302 3.7 11.1 0.5 O B:GLY272 3.7 13.2 1.0 CA B:GLY275 3.8 12.8 1.0 N B:PRO301 3.9 10.4 1.0 CB B:PRO301 3.9 11.1 1.0 CB B:SER302 3.9 10.9 0.5 CA B:SER302 3.9 11.0 0.5 CA B:SER302 4.0 10.8 0.5 N B:SER274 4.0 13.7 0.5 CB B:SER274 4.0 13.2 0.5 N B:SER274 4.0 14.2 0.5 OG B:SER302 4.1 11.4 0.5 CG B:PRO301 4.1 11.4 1.0 C B:SER274 4.1 13.0 0.5 C B:SER274 4.1 13.5 0.5 C B:SER302 4.1 10.6 0.5 CB B:CYS271 4.1 14.2 1.0 C B:SER302 4.2 10.6 0.5 C B:PRO301 4.2 11.1 1.0 CA B:PRO301 4.2 10.8 1.0 O B:FGA1328 4.2 26.4 1.0 CA B:SER274 4.2 13.3 0.5 CB B:SER274 4.3 14.7 0.5 CA B:SER274 4.3 14.2 0.5 C B:CYS271 4.3 13.3 1.0 N B:PHE273 4.3 13.4 1.0 CA B:CYS271 4.7 13.3 1.0 SG B:CYS271 4.7 14.9 1.0 C B:ILE300 4.7 11.0 1.0 C B:PHE273 4.8 13.9 1.0 OG B:SER274 5.0 12.9 0.5

P.K.Fyfe, G.D.Westrop, T.Ramos, S.Muller, G.H.Coombs, W.N.Hunter. Structure of Leishmania Major Cysteine Synthase. Acta Crystallogr.,Sect.F V. 68 738 2012.
ISSN: ISSN 1744-3091
PubMed: 22750854
DOI: 10.1107/S1744309112019124