Chlorine »
PDB 4b4j-4bbp »
4bae »
Chlorine in PDB 4bae: Optimisation of Pyrroleamides As Mycobacterial Gyrb Atpase Inhibitors: Structure Activity Relationship and in Vivo Efficacy in the Mouse Model of Tuberculosis
Enzymatic activity of Optimisation of Pyrroleamides As Mycobacterial Gyrb Atpase Inhibitors: Structure Activity Relationship and in Vivo Efficacy in the Mouse Model of Tuberculosis
All present enzymatic activity of Optimisation of Pyrroleamides As Mycobacterial Gyrb Atpase Inhibitors: Structure Activity Relationship and in Vivo Efficacy in the Mouse Model of Tuberculosis:
5.99.1.3;
5.99.1.3;
Protein crystallography data
The structure of Optimisation of Pyrroleamides As Mycobacterial Gyrb Atpase Inhibitors: Structure Activity Relationship and in Vivo Efficacy in the Mouse Model of Tuberculosis, PDB code: 4bae
was solved by
J.A.Read,
H.G.Gingell,
P.Madhavapeddi,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 59.19 / 2.35 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 59.191, 78.249, 89.750, 90.00, 90.01, 90.00 |
| R / Rfree (%) | 19.42 / 23.72 |
Other elements in 4bae:
The structure of Optimisation of Pyrroleamides As Mycobacterial Gyrb Atpase Inhibitors: Structure Activity Relationship and in Vivo Efficacy in the Mouse Model of Tuberculosis also contains other interesting chemical elements:
| Bromine | (Br) | 4 atoms |
| Calcium | (Ca) | 4 atoms |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Optimisation of Pyrroleamides As Mycobacterial Gyrb Atpase Inhibitors: Structure Activity Relationship and in Vivo Efficacy in the Mouse Model of Tuberculosis
(pdb code 4bae). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Optimisation of Pyrroleamides As Mycobacterial Gyrb Atpase Inhibitors: Structure Activity Relationship and in Vivo Efficacy in the Mouse Model of Tuberculosis, PDB code: 4bae:
Jump to Chlorine binding site number: 1; 2; 3; 4;
In total 4 binding sites of Chlorine where determined in the Optimisation of Pyrroleamides As Mycobacterial Gyrb Atpase Inhibitors: Structure Activity Relationship and in Vivo Efficacy in the Mouse Model of Tuberculosis, PDB code: 4bae:
Jump to Chlorine binding site number: 1; 2; 3; 4;
Chlorine binding site 1 out of 4 in 4bae
Go back to
Chlorine Binding Sites List in 4bae
Chlorine binding site 1 out
of 4 in the Optimisation of Pyrroleamides As Mycobacterial Gyrb Atpase Inhibitors: Structure Activity Relationship and in Vivo Efficacy in the Mouse Model of Tuberculosis
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Optimisation of Pyrroleamides As Mycobacterial Gyrb Atpase Inhibitors: Structure Activity Relationship and in Vivo Efficacy in the Mouse Model of Tuberculosis within 5.0Å range:
|
Chlorine binding site 2 out of 4 in 4bae
Go back to
Chlorine Binding Sites List in 4bae
Chlorine binding site 2 out
of 4 in the Optimisation of Pyrroleamides As Mycobacterial Gyrb Atpase Inhibitors: Structure Activity Relationship and in Vivo Efficacy in the Mouse Model of Tuberculosis
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Optimisation of Pyrroleamides As Mycobacterial Gyrb Atpase Inhibitors: Structure Activity Relationship and in Vivo Efficacy in the Mouse Model of Tuberculosis within 5.0Å range:
|
Chlorine binding site 3 out of 4 in 4bae
Go back to
Chlorine Binding Sites List in 4bae
Chlorine binding site 3 out
of 4 in the Optimisation of Pyrroleamides As Mycobacterial Gyrb Atpase Inhibitors: Structure Activity Relationship and in Vivo Efficacy in the Mouse Model of Tuberculosis
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of Optimisation of Pyrroleamides As Mycobacterial Gyrb Atpase Inhibitors: Structure Activity Relationship and in Vivo Efficacy in the Mouse Model of Tuberculosis within 5.0Å range:
|
Chlorine binding site 4 out of 4 in 4bae
Go back to
Chlorine Binding Sites List in 4bae
Chlorine binding site 4 out
of 4 in the Optimisation of Pyrroleamides As Mycobacterial Gyrb Atpase Inhibitors: Structure Activity Relationship and in Vivo Efficacy in the Mouse Model of Tuberculosis
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 4 of Optimisation of Pyrroleamides As Mycobacterial Gyrb Atpase Inhibitors: Structure Activity Relationship and in Vivo Efficacy in the Mouse Model of Tuberculosis within 5.0Å range:
|
Reference:
S.P.Hameed,
S.Solapure,
K.Mukherjee,
V.Nandi,
D.Waterson,
R.Shandil,
M.Balganesh,
V.K.Sambandamurthy,
A.K.Raichurkar,
A.Deshpande,
A.Ghosh,
D.Awasthy,
G.Shanbhag,
G.Sheikh,
H.Mcmiken,
J.Puttur,
J.Reddy,
J.Werngren,
J.Read,
M.Kumar,
M.R,
M.Chinnapattu,
P.Madhavapeddi,
P.Manjrekar,
R.Basu,
S.Gaonkar,
S.Sharma,
S.Hoffner,
V.Humnabadkar,
V.Subbulakshmi,
V.Panduga.
Optimization of Pyrrolamides As Mycobacterial Gyrb Atpase Inhibitors: Structure Activity Relationship and in Vivo Efficacy in the Mouse Model of Tuberculosis. Antimicrob.Agents Chemother. V. 58 61 2014.
ISSN: ISSN 0066-4804
PubMed: 24126580
DOI: 10.1128/AAC.01751-13
Page generated: Fri Jul 11 13:14:32 2025
ISSN: ISSN 0066-4804
PubMed: 24126580
DOI: 10.1128/AAC.01751-13
Last articles
Na in 1S3XNa in 1S36
Na in 1S0A
Na in 1S1K
Na in 1S09
Na in 1RZT
Na in 1S08
Na in 1S07
Na in 1S06
Na in 1RYS
