Chlorine »
PDB 4bbz-4bjy »
4bda »
Chlorine in PDB 4bda: Fragment-Based Screening Identifies A New Area For Inhibitor Binding to Checkpoint Kinase 2 (CHK2)
Enzymatic activity of Fragment-Based Screening Identifies A New Area For Inhibitor Binding to Checkpoint Kinase 2 (CHK2)
All present enzymatic activity of Fragment-Based Screening Identifies A New Area For Inhibitor Binding to Checkpoint Kinase 2 (CHK2):
2.7.11.1;
2.7.11.1;
Protein crystallography data
The structure of Fragment-Based Screening Identifies A New Area For Inhibitor Binding to Checkpoint Kinase 2 (CHK2), PDB code: 4bda
was solved by
M.C.Silva-Santisteban,
I.M.Westwood,
K.Boxall,
N.Brown,
S.Peacock,
C.Mcandrew,
E.Barrie,
M.Richards,
A.Mirza,
A.W.Oliver,
R.Burke,
S.Hoelder,
K.Jones,
G.W.Aherne,
J.Blagg,
I.Collins,
M.D.Garrett,
R.L.M.Van Montfort,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 22.68 / 2.60 |
| Space group | P 32 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 91.130, 91.130, 93.110, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 18.04 / 23.65 |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Fragment-Based Screening Identifies A New Area For Inhibitor Binding to Checkpoint Kinase 2 (CHK2)
(pdb code 4bda). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Fragment-Based Screening Identifies A New Area For Inhibitor Binding to Checkpoint Kinase 2 (CHK2), PDB code: 4bda:
In total only one binding site of Chlorine was determined in the Fragment-Based Screening Identifies A New Area For Inhibitor Binding to Checkpoint Kinase 2 (CHK2), PDB code: 4bda:
Chlorine binding site 1 out of 1 in 4bda
Go back to
Chlorine Binding Sites List in 4bda
Chlorine binding site 1 out
of 1 in the Fragment-Based Screening Identifies A New Area For Inhibitor Binding to Checkpoint Kinase 2 (CHK2)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Fragment-Based Screening Identifies A New Area For Inhibitor Binding to Checkpoint Kinase 2 (CHK2) within 5.0Å range:
|
Reference:
M.C.Silva-Santisteban,
I.M.Westwood,
K.Boxall,
N.Brown,
S.Peacock,
C.Mcandrew,
E.Barrie,
M.Richards,
A.Mirza,
A.W.Oliver,
R.Burke,
S.Hoelder,
K.Jones,
G.W.Aherne,
J.Blagg,
I.Collins,
M.D.Garrett,
R.L.Van Montfort.
Fragment-Based Screening Maps Inhibitor Interactions in the Atp-Binding Site of Checkpoint Kinase 2. Plos One V. 8 65689 2013.
ISSN: ISSN 1932-6203
PubMed: 23776527
DOI: 10.1371/JOURNAL.PONE.0065689
Page generated: Sun Jul 21 10:00:01 2024
ISSN: ISSN 1932-6203
PubMed: 23776527
DOI: 10.1371/JOURNAL.PONE.0065689
Last articles
Zn in 9MJ5Zn in 9HNW
Zn in 9G0L
Zn in 9FNE
Zn in 9DZN
Zn in 9E0I
Zn in 9D32
Zn in 9DAK
Zn in 8ZXC
Zn in 8ZUF
