|
Atomistry » Chlorine » PDB 4ck8-4cqb » 4ck9 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 4ck8-4cqb » 4ck9 » |
Chlorine in PDB 4ck9: Sterol 14-Alpha Demethylase (CYP51)From Trypanosoma Cruzi in Complex with (S)-1-(4-Chlorophenyl)-2-(1H-Imidazol-1-Yl) Ethyl 4-Isopropylphenylcarbamate (Lft)Enzymatic activity of Sterol 14-Alpha Demethylase (CYP51)From Trypanosoma Cruzi in Complex with (S)-1-(4-Chlorophenyl)-2-(1H-Imidazol-1-Yl) Ethyl 4-Isopropylphenylcarbamate (Lft)
All present enzymatic activity of Sterol 14-Alpha Demethylase (CYP51)From Trypanosoma Cruzi in Complex with (S)-1-(4-Chlorophenyl)-2-(1H-Imidazol-1-Yl) Ethyl 4-Isopropylphenylcarbamate (Lft):
1.14.13.70; Protein crystallography data
The structure of Sterol 14-Alpha Demethylase (CYP51)From Trypanosoma Cruzi in Complex with (S)-1-(4-Chlorophenyl)-2-(1H-Imidazol-1-Yl) Ethyl 4-Isopropylphenylcarbamate (Lft), PDB code: 4ck9
was solved by
L.Friggeri,
Z.Wawrzak,
S.Tortorella,
G.I.Lepesheva,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4ck9:
The structure of Sterol 14-Alpha Demethylase (CYP51)From Trypanosoma Cruzi in Complex with (S)-1-(4-Chlorophenyl)-2-(1H-Imidazol-1-Yl) Ethyl 4-Isopropylphenylcarbamate (Lft) also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Sterol 14-Alpha Demethylase (CYP51)From Trypanosoma Cruzi in Complex with (S)-1-(4-Chlorophenyl)-2-(1H-Imidazol-1-Yl) Ethyl 4-Isopropylphenylcarbamate (Lft)
(pdb code 4ck9). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Sterol 14-Alpha Demethylase (CYP51)From Trypanosoma Cruzi in Complex with (S)-1-(4-Chlorophenyl)-2-(1H-Imidazol-1-Yl) Ethyl 4-Isopropylphenylcarbamate (Lft), PDB code: 4ck9: Chlorine binding site 1 out of 1 in 4ck9Go back to![]() ![]()
Chlorine binding site 1 out
of 1 in the Sterol 14-Alpha Demethylase (CYP51)From Trypanosoma Cruzi in Complex with (S)-1-(4-Chlorophenyl)-2-(1H-Imidazol-1-Yl) Ethyl 4-Isopropylphenylcarbamate (Lft)
![]() Mono view ![]() Stereo pair view
Reference:
L.Friggeri,
T.Y.Hargrove,
G.Rachakonda,
A.D.Williams,
Z.Wawrzak,
R.Di Santo,
D.De Vita,
M.R.Waterman,
S.Tortorella,
F.Villalta,
G.I.Lepesheva.
Structural Basis For Rational Design of Inhibitors Targeting Trypanosoma Cruzi Sterol 14ALPHA-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its Inhibition. J.Med.Chem. V. 57 6704 2014.
Page generated: Sun Jul 21 11:19:00 2024
ISSN: ISSN 0022-2623 PubMed: 25033013 DOI: 10.1021/JM500739F |
Last articlesZn in 9MJ5Zn in 9HNW Zn in 9G0L Zn in 9FNE Zn in 9DZN Zn in 9E0I Zn in 9D32 Zn in 9DAK Zn in 8ZXC Zn in 8ZUF |
© Copyright 2008-2020 by atomistry.com | ||
Home | Site Map | Copyright | Contact us | Privacy |