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Atomistry » Chlorine » PDB 4da5-4dhn » 4dbw | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 4da5-4dhn » 4dbw » |
Chlorine in PDB 4dbw: Crystal Structure of Human 17BETA-Hydroxysteroid Dehydrogenase Type 5 (AKR1C3) in Complex with Nadp+ and 2'-Desmethyl-IndomethacinEnzymatic activity of Crystal Structure of Human 17BETA-Hydroxysteroid Dehydrogenase Type 5 (AKR1C3) in Complex with Nadp+ and 2'-Desmethyl-Indomethacin
All present enzymatic activity of Crystal Structure of Human 17BETA-Hydroxysteroid Dehydrogenase Type 5 (AKR1C3) in Complex with Nadp+ and 2'-Desmethyl-Indomethacin:
1.1.1.112; 1.1.1.188; 1.1.1.213; 1.1.1.63; 1.1.1.64; 1.3.1.20; Protein crystallography data
The structure of Crystal Structure of Human 17BETA-Hydroxysteroid Dehydrogenase Type 5 (AKR1C3) in Complex with Nadp+ and 2'-Desmethyl-Indomethacin, PDB code: 4dbw
was solved by
M.Chen,
D.W.Christianson,
L.J.Marnett,
T.M.Penning,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Human 17BETA-Hydroxysteroid Dehydrogenase Type 5 (AKR1C3) in Complex with Nadp+ and 2'-Desmethyl-Indomethacin
(pdb code 4dbw). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Crystal Structure of Human 17BETA-Hydroxysteroid Dehydrogenase Type 5 (AKR1C3) in Complex with Nadp+ and 2'-Desmethyl-Indomethacin, PDB code: 4dbw: Jump to Chlorine binding site number: 1; 2; 3; 4; Chlorine binding site 1 out of 4 in 4dbwGo back to![]() ![]()
Chlorine binding site 1 out
of 4 in the Crystal Structure of Human 17BETA-Hydroxysteroid Dehydrogenase Type 5 (AKR1C3) in Complex with Nadp+ and 2'-Desmethyl-Indomethacin
![]() Mono view ![]() Stereo pair view
Chlorine binding site 2 out of 4 in 4dbwGo back to![]() ![]()
Chlorine binding site 2 out
of 4 in the Crystal Structure of Human 17BETA-Hydroxysteroid Dehydrogenase Type 5 (AKR1C3) in Complex with Nadp+ and 2'-Desmethyl-Indomethacin
![]() Mono view ![]() Stereo pair view
Chlorine binding site 3 out of 4 in 4dbwGo back to![]() ![]()
Chlorine binding site 3 out
of 4 in the Crystal Structure of Human 17BETA-Hydroxysteroid Dehydrogenase Type 5 (AKR1C3) in Complex with Nadp+ and 2'-Desmethyl-Indomethacin
![]() Mono view ![]() Stereo pair view
Chlorine binding site 4 out of 4 in 4dbwGo back to![]() ![]()
Chlorine binding site 4 out
of 4 in the Crystal Structure of Human 17BETA-Hydroxysteroid Dehydrogenase Type 5 (AKR1C3) in Complex with Nadp+ and 2'-Desmethyl-Indomethacin
![]() Mono view ![]() Stereo pair view
Reference:
A.J.Liedtke,
A.O.Adeniji,
M.Chen,
M.C.Byrns,
Y.Jin,
D.W.Christianson,
L.J.Marnett,
T.M.Penning.
Development of Potent and Selective Indomethacin Analogues For the Inhibition of AKR1C3 (Type 5 17 Beta-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Prostate Cancer. J.Med.Chem. V. 56 2429 2013.
Page generated: Sun Jul 21 11:54:32 2024
ISSN: ISSN 0022-2623 PubMed: 23432095 DOI: 10.1021/JM3017656 |
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