Chlorine in PDB 4dgy: Structure of the Hepatitis C Virus Envelope Glycoprotein E2 Antigenic Region 412-423 Bound to the Broadly Neutralizing Antibody HCV1, C2 Form

The structure of Structure of the Hepatitis C Virus Envelope Glycoprotein E2 Antigenic Region 412-423 Bound to the Broadly Neutralizing Antibody HCV1, C2 Form, PDB code: 4dgy was solved by L.Kong, I.A.Wilson, M.Law, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	28.76 / 1.80
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	141.099, 63.065, 69.300, 90.00, 95.72, 90.00
R / Rfree (%)	18.8 / 22.1

The binding sites of Chlorine atom in the Structure of the Hepatitis C Virus Envelope Glycoprotein E2 Antigenic Region 412-423 Bound to the Broadly Neutralizing Antibody HCV1, C2 Form (pdb code 4dgy). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Structure of the Hepatitis C Virus Envelope Glycoprotein E2 Antigenic Region 412-423 Bound to the Broadly Neutralizing Antibody HCV1, C2 Form, PDB code: 4dgy:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Structure of the Hepatitis C Virus Envelope Glycoprotein E2 Antigenic Region 412-423 Bound to the Broadly Neutralizing Antibody HCV1, C2 Form


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of the Hepatitis C Virus Envelope Glycoprotein E2 Antigenic Region 412-423 Bound to the Broadly Neutralizing Antibody HCV1, C2 Form within 5.0Å range: probe atom residue distance (Å) B Occ H:Cl303 b:36.3 occ:1.00 OH H:TYR145 3.0 27.9 1.0 N H:VAL150 3.3 30.2 1.0 O H:HOH466 3.3 44.4 1.0 CA H:PRO149 3.4 35.5 1.0 CG H:GLU148 3.8 30.0 1.0 CZ H:TYR145 3.8 27.2 1.0 C H:PRO149 3.8 33.1 1.0 CE2 H:TYR145 3.9 26.3 1.0 CB H:ALA168 3.9 29.9 1.0 CG2 H:VAL150 3.9 34.8 1.0 CB H:GLU148 3.9 24.8 1.0 CB H:PRO149 3.9 32.7 1.0 OE2 H:GLU148 4.0 42.2 1.0 CD1 H:LEU178 4.2 28.2 1.0 O H:VAL150 4.2 33.9 1.0 CD H:GLU148 4.3 45.8 1.0 CA H:GLU148 4.3 27.9 1.0 CA H:VAL150 4.4 28.8 1.0 N H:PRO149 4.6 30.2 1.0 O H:HOH511 4.7 51.1 1.0 CB H:VAL150 4.7 31.3 1.0 C H:VAL150 4.8 39.1 1.0

Chlorine binding site 2 out of 2 in the Structure of the Hepatitis C Virus Envelope Glycoprotein E2 Antigenic Region 412-423 Bound to the Broadly Neutralizing Antibody HCV1, C2 Form


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of the Hepatitis C Virus Envelope Glycoprotein E2 Antigenic Region 412-423 Bound to the Broadly Neutralizing Antibody HCV1, C2 Form within 5.0Å range: probe atom residue distance (Å) B Occ H:Cl304 b:40.0 occ:1.00 N H:TYR59 3.1 23.9 1.0 O H:HOH564 3.1 48.5 1.0 NE H:ARG64 3.2 40.5 1.0 NH2 H:ARG64 3.6 38.1 1.0 CA H:TYR58 3.7 25.0 1.0 O H:TYR59 3.7 26.6 1.0 CZ H:ARG64 3.9 39.0 1.0 C H:TYR58 3.9 21.4 1.0 CD1 H:TYR58 4.0 34.8 1.0 CA H:TYR59 4.1 26.2 1.0 CB H:TYR58 4.1 24.6 1.0 CB H:TYR59 4.2 28.9 1.0 CD H:ARG64 4.2 41.4 1.0 CD2 H:TYR59 4.3 30.9 1.0 CH2 L:TRP94 4.3 36.1 1.0 C H:TYR59 4.3 24.2 1.0 CG H:TYR58 4.5 28.3 1.0 CG H:TYR59 4.7 25.7 1.0 CZ3 L:TRP94 4.8 36.1 1.0 CG H:ARG64 4.8 36.2 1.0 O H:LYS57 4.8 30.2 1.0 N H:TYR58 5.0 27.0 1.0 CE1 H:TYR58 5.0 35.6 1.0

L.Kong, E.Giang, J.B.Robbins, R.L.Stanfield, D.R.Burton, I.A.Wilson, M.Law. Structural Basis of Hepatitis C Virus Neutralization By Broadly Neutralizing Antibody HCV1. Proc.Natl.Acad.Sci.Usa V. 109 9499 2012.
ISSN: ISSN 0027-8424
PubMed: 22623528
DOI: 10.1073/PNAS.1202924109