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Chlorine in PDB 4gcd: Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 2

Enzymatic activity of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 2

All present enzymatic activity of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 2:
3.2.1.17;

Protein crystallography data

The structure of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 2, PDB code: 4gcd was solved by J.R.Helliwell, S.W.M.Tanley, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 35.74 / 2.80
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 79.863, 79.863, 37.802, 90.00, 90.00, 90.00
R / Rfree (%) 17.5 / 24

Other elements in 4gcd:

The structure of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 2 also contains other interesting chemical elements:

Platinum (Pt) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 2 (pdb code 4gcd). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 2, PDB code: 4gcd:

Chlorine binding site 1 out of 1 in 4gcd

Go back to Chlorine Binding Sites List in 4gcd
Chlorine binding site 1 out of 1 in the Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 2


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 2 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl204

b:45.6
occ:0.66
 CL2 A:CPT204 0.0 45.6 0.7
PT1 A:CPT204 2.4 64.2 0.7
OD1 A:ASN93 2.7 36.2 1.0
N2 A:CPT204 3.0 58.9 0.7
ND1 A:HIS15 3.3 49.2 1.0
CG A:ASN93 3.8 34.9 1.0
CG1 A:VAL92 3.9 25.4 1.0
NZ A:LYS96 3.9 37.8 1.0
O A:HIS15 3.9 40.1 1.0
CG A:HIS15 4.3 46.2 1.0
CG2 A:THR89 4.3 33.0 1.0
CE1 A:HIS15 4.3 50.1 1.0
ND2 A:ASN93 4.3 37.4 1.0
CB A:HIS15 4.3 43.6 1.0
O A:THR89 4.4 29.9 1.0
CA A:HIS15 4.5 43.0 1.0
C A:HIS15 4.6 41.4 1.0
CB A:VAL92 4.6 24.8 1.0
N A:ASN93 4.7 27.2 1.0
CE A:LYS96 4.7 35.5 1.0
CA A:THR89 5.0 30.3 1.0
CB A:ASN93 5.0 31.8 1.0

Reference:

J.R.Helliwell, S.W.Tanley. The Crystal Structure Analysis of the Relative Binding of Cisplatin and Carboplatin in A Mixture with Histidine in A Protein Studied at 100 and 300 K with Repeated X-Ray Irradiation. Acta Crystallogr.,Sect.D V. 69 121 2013.
ISSN: ISSN 0907-4449
PubMed: 23275170
DOI: 10.1107/S090744491204423X
Page generated: Fri Jul 11 15:36:00 2025

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