Chlorine in PDB 4gk8: Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate

Enzymatic activity of Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate

All present enzymatic activity of Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate:
3.1.3.15;

Protein crystallography data

The structure of Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate, PDB code: 4gk8 was solved by A.A.Fedorov, E.V.Fedorov, S.Ghodge, F.M.Raushel, S.C.Almo, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	43.31 / 1.93
*Space group*	P 2₁ 2₁ 2
*Cell size a, b, c (Å), α, β, γ (°)*	85.860, 86.622, 45.093, 90.00, 90.00, 90.00
*R / R_free (%)*	16.2 / 19.6

Other elements in 4gk8:

The structure of Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate also contains other interesting chemical elements:

Arsenic	(As)	1 atom
Zinc	(Zn)	4 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate (pdb code 4gk8). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate, PDB code: 4gk8:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in 4gk8

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Chlorine Binding Sites List in 4gk8

Chlorine binding site 1 out of 3 in the Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl306 b:24.2 occ:1.00	ZN	A:ZN304	2.2	21.4	1.0
	O	A:HOH409	3.2	18.6	1.0
	N3	A:IMD309	3.4	21.6	1.0
	NE2	A:HIS32	3.5	20.7	1.0
	NE2	A:HIS240	3.5	22.4	1.0
	CD2	A:HIS240	3.7	21.0	1.0
	CD2	A:HIS32	3.7	16.2	1.0
	CG2	A:ILE239	3.7	20.3	1.0
	CD	A:ARG243	3.9	21.6	1.0
	CD2	A:LEU34	4.0	16.7	1.0
	C2	A:IMD309	4.0	23.7	1.0
	NE	A:ARG243	4.1	20.2	1.0
	C4	A:IMD309	4.3	21.8	1.0
	CE3	A:TRP236	4.4	20.7	1.0
	CZ3	A:TRP236	4.4	19.8	1.0
	CZ	A:ARG243	4.5	26.9	1.0
	CG	A:LYS5	4.6	20.9	1.0
	NH1	A:ARG243	4.6	23.8	1.0
	CB	A:LYS5	4.7	18.5	1.0
	CE1	A:HIS32	4.8	18.6	1.0
	CE1	A:HIS240	4.8	19.2	1.0
	CB	A:ILE239	4.9	21.8	1.0
	CG	A:HIS240	5.0	20.0	1.0

Chlorine binding site 2 out of 3 in 4gk8

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Chlorine Binding Sites List in 4gk8

Chlorine binding site 2 out of 3 in the Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl307 b:28.5 occ:1.00	N	A:TYR46	3.2	20.7	1.0
	NH1	A:ARG43	3.3	20.6	1.0
	NH2	A:ARG43	3.3	21.3	1.0
	CA	A:PHE45	3.7	21.9	1.0
	O	A:HOH418	3.7	22.0	1.0
	CZ	A:ARG43	3.7	24.9	1.0
	C	A:PHE45	3.9	19.1	1.0
	CD1	A:TYR46	4.0	25.4	1.0
	OD1	A:ASP51	4.1	50.0	1.0
	CD2	A:PHE45	4.1	27.3	1.0
	O	A:ASP44	4.1	19.4	1.0
	CA	A:TYR46	4.1	20.6	1.0
	CE1	A:TYR46	4.2	21.3	1.0
	CB	A:PHE45	4.3	24.3	1.0
	CG	A:PHE45	4.4	24.0	1.0
	CG	A:TYR46	4.5	23.0	1.0
	N	A:PHE45	4.7	19.3	1.0
	CZ	A:TYR46	4.8	20.0	1.0
	CE2	A:PHE45	4.8	26.6	1.0
	C	A:ASP44	4.8	19.7	1.0
	CB	A:TYR46	5.0	20.0	1.0

Chlorine binding site 3 out of 3 in 4gk8

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Chlorine Binding Sites List in 4gk8

Chlorine binding site 3 out of 3 in the Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl308 b:24.9 occ:1.00	N	A:GLU147	3.2	21.7	1.0
	ND2	A:ASN93	3.4	22.5	1.0
	CE	A:LYS89	3.6	29.9	1.0
	CD1	A:PHE146	3.7	24.0	1.0
	N	A:ASN148	3.7	18.1	1.0
	CA	A:GLU147	4.0	22.0	1.0
	CB	A:GLU147	4.0	27.1	1.0
	OD1	A:ASN93	4.0	20.6	1.0
	CG	A:GLU147	4.1	39.2	1.0
	CA	A:PHE146	4.1	21.0	1.0
	CE1	A:PHE146	4.1	23.2	1.0
	C	A:PHE146	4.1	20.0	1.0
	CG	A:ASN93	4.2	23.8	1.0
	NZ	A:LYS89	4.2	30.1	1.0
	CB	A:ASN148	4.2	20.7	1.0
	C	A:GLU147	4.3	19.4	1.0
	CG	A:PHE146	4.4	20.3	1.0
	CA	A:ASN148	4.6	18.9	1.0
	CB	A:PHE146	4.8	19.0	1.0
	CD	A:LYS89	4.8	24.4	1.0
	O	A:ASN145	4.9	25.6	1.0
	CG	A:LYS89	4.9	23.4	1.0
	CZ	A:PHE146	5.0	16.5	1.0

Reference:

S.V.Ghodge, A.A.Fedorov, E.V.Fedorov, B.Hillerich, R.Seidel, S.C.Almo, F.M.Raushel. Structural and Mechanistic Characterization of L-Histidinol Phosphate Phosphatase From the Polymerase and Histidinol Phosphatase Family of Proteins. Biochemistry V. 52 1101 2013.
ISSN: ISSN 0006-2960
PubMed: 23327428
DOI: 10.1021/BI301496P

Page generated: Fri Jul 11 15:44:06 2025

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